meclofenamate; Meclomen (cont.)

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PREPARATIONS: Capsules: 50 and 100 mg.

STORAGE: Meclofenamate should be stored at 20 C to 25 C (68 F to 77 F) in a sealed container protected from light and moisture.

PRESCRIBED FOR: Meclofenamate is used for the relief of mild to moderate pain. It also is used to treat dysmenorrhea (painful periods), idiopathic heavy menstrual blood loss, and relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis. Off label uses include ankylosing spondylitis (arthritis that mainly affects the spine) and vascular headache.

DOSING: The usual dose for mild to moderate pain is 50 to 100 mg every 4 to 6 hours.

For excessive menstrual blood loss and primary dysmenorrhea the usual dose is 100 mg three times a day, for up to six days. The maximum dose is 300 mg daily.

For rheumatoid arthritis and osteoarthritis the usual dose is 50 to 100 mg 3 to 4 times a day. The maximum dose is 400 mg daily..

DRUG INTERACTIONS: Concurrent use of meclofenamate and warfarin (Coumadin), a blood thinner, may cause excessive bleeding as meclofenamate enhances the effect of warfarin. It is important, therefore, to reduce the dosage of warfarin.

Meclofenamate, as other NSAIDS may reduce the effects of blood pressure-lowering medications. This may occur because prostaglandins are important in the regulation of blood pressure.

Concurrent use of meclofenamate and cyclosporine (Sandimmune), an immunosuppressant, can increase the risk of kidney damage (nephrotoxicity), as meclofenamate tends to increase cyclosporine-induced kidney damage by blocking certain prostaglandins that are important in preventing toxic effects on the kidney. It is important, therefore, to avoid this combination and/or monitor kidney function and blood pressure.

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