meclofenamate, Meclomen

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GENERIC NAME: meclofenamate

BRAND NAME: Meclomen, Meclodium (These brands no longer are available in the U.S.)

DRUG CLASS AND MECHANISM: Meclofenamate belongs to a class of drugs called nonsteroidal antiinflammatory drugs (NSAIDs). Other NSAIDS include ibuprofen (Motrin), indomethacin (Indocin), naproxen (Naprosyn, Aleve, Anaprox, Naprelan), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Meclofenamate blocks the enzymes that make prostaglandins (cyclooxygenases), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain, and fever are reduced. Meclofenamate was approved by the FDA in June 1980.



PREPARATIONS: Capsules: 50 and 100 mg.

STORAGE: Meclofenamate should be stored at 20 to 25 C (68 to 77 F) in a sealed container protected from light and moisture.

PRESCRIBED FOR: Meclofenamate is used for the relief of mild to moderate pain. It also is used to treat dysmenorrhea (painful periods), idiopathic heavy menstrual blood loss, and relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis. Off label uses include ankylosing spondylitis (arthritis that mainly affects the spine) and vascular headache.

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