meclizine, Antivert, Bonine, Meni-D, Antrizine

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

Balance Disorders: Vertigo, Migraines, Motion Sickness and More

What is meclizine, and how does it work (mechanism of action)?

Meclizine is an antihistamine with antiemetic (anti-nausea) and antispasmodic (anti-muscle spasm) activity. It also suppresses the nervous system by blocking the action of the neurotransmitter acetylcholine. (Neurotransmitters are chemicals that nerves use for communicating with each other.) Meclizine prevents nausea and vomiting by reducing the activity of the center in the brain that controls nausea. It also prevents motion sickness by reducing excitability of neurons in the motion and balance center (vestibular region) of the brain. The FDA approved meclizine in February 1957.

Is meclizine available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for meclizine?

: Yes, depending on strengths there are none prescription strength products available,

What are the side effects of meclizine?

Meclizine can cause drowsiness. Other side effects include:

Meclizine also has been associated with hypotension (low blood pressure) and heart palpitations.

What is the dosage for meclizine?

When used for treating symptoms of motion sickness, meclizine 12.5-50 mg should be taken one hour prior to travel and then every 24 hours for the duration of the journey. The dosing should not exceed 50 mg  in 24 hours. Vertigo is treated with 25-100 mg daily in a single dose or in 4 divided dose

Which drugs or supplements interact with meclizine?

: Alcohol, sedatives, and tranquilizers can increase drowsiness caused by meclizine. Combining meclizine with pramlintide (Symlin) increases the effect of both drugs on slowing bowel movement.

Is meclizine safe to take if I'm pregnant or breastfeeding?

Available information suggests that the risk of harm to the baby is minimal when meclizine is used while breastfeeding.

What else should I know about meclizine?

What preparations of meclizine are available?

Tablets: 12.5, 25, and 50 mg. Chewable Tablets: 25 mg

How should I keep meclizine stored?

Meclizine tablets should be stored between 15 C and 30 C (59 and 86 F). Capsules should be stored below 30 C (86 F).

Reference: FDA Prescribing Information

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See more info: meclizine on RxList
Reviewed on 9/18/2015
References
Reference: FDA Prescribing Information

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