mebendazole, Vermox (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Chewable tablets: 100 mg

STORAGE: Mebendazole should be protected from light and stored at room temperature, between 15 C to 30 C (59 F to 86 F).

DOSING: Recommendations are based on the infecting organism being treated.

  • Initial dosing for some hookworm, roundworm, tapeworm, and whipworm infections is 100 mg twice daily for 3 days.
  • Initial dosing for pinworm infection is 100 mg as a single dose. The dose may be repeated in 2 to 3 weeks if needed.

DRUG INTERACTIONS:

  • Mebendazole should not be used with metronidazole (Flagyl) due to the increased risk of rare but serious life-threatening skin conditions known as Stevens-Johnson syndrome and toxic epidermal necrolysis.
  • Carbamazepine (Tegretol, Tegretol SR, Equetro, Carbatrol), fosphenytoin (Cerebyx), ethotoin (Peganone), and phenytoin (Dilantin, Dilantin-125) may interfere with successful treatment with mebendazole by decreasing its blood levels.
  • Cimetidine (Tagamet) may increase mebendazole levels and increase the risk of side effects from mebendazole.

PREGNANCY: Adverse outcomes in animal studies have been observed. Adverse outcomes in human pregnancy have not been seen, however the Centers for Disease Control recommends postponing pinworm therapy until the third trimester when possible.

NURSING MOTHERS: While excretion into breast milk is unlikely, caution should be used since data is not available on excretion of mebendazole into breast milk.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 7/31/2015


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