MAOIs (Monoamine Oxidase Inhibitors, MAOI) (cont.)

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Selegiline is also available in a topical patch form called Emsam.

What are the side effects of MAOIs?

Since MAOIs work in brain and affect neurotransmitters, they have many side effects. Side effects of MAOIs are:

MAOIs also carry boxed warnings of suicidal thinking and suicidal behavior in children, adolescents, and young adults.

What drugs interact with MAOIs?

MAO inhibitors should be avoided with other antidepressants such as paroxetine fluoxetine, amitriptyline, nortriptyline, bupropion; pain medications like methadone, tramadol, and meperidine; dextromethorphan, St. Johns Wort, cyclobenzaprine, and mirtazapine. Such combinations lead to high serotonin levels which may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death.

Medically Reviewed by a Doctor on 7/2/2014


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