MAOIs (Monoamine Oxidase Inhibitors, MAOI) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

MAOIs also carry boxed warnings of suicidal thinking and suicidal behavior in children, adolescents, and young adults.

What are examples of MAOIs available in the US?

Examples of oral MAOIs include:

  • rasagiline (Azilect),
  • selegiline (Eldepryl, Zelapar),
  • isocarboxazid (Marplan),
  • phenelzine (Nardil), and
  • tranylcypromine (Parnate).

Selegiline is also available in a topical patch form called Emsam.

What drugs interact with MAOIs?

MAO inhibitors should be avoided with other antidepressants such as paroxetine fluoxetine, amitriptyline, nortriptyline, bupropion; pain medications like methadone, tramadol, and meperidine; dextromethorphan, St. Johns Wort, cyclobenzaprine, and mirtazapine. Such combinations lead to high serotonin levels which may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. These medications should not be used within 14 days of stopping an MAOI.

MAOIs also interact with seizure medications like carbamazepine (Tegretol Tegretol XR, Equetro, Carbatrol)and oxcarbazepine (Trileptal) through unknown mechanisms, increasing side effects.

Medically Reviewed by a Doctor on 3/27/2015


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