Monoamine Oxidase Inhibitors (MAOIs) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

MAOIs also interact with seizure medications like carbamazepine (Tegretol TEgretol XR, Equetro, Carbatrol)and oxcarbazepine (Trileptal) through unknown mechanisms, increasing side effects.

MAOIs inhibitors are not recommended for use with medications like pseudoephedrine, phenylephrine, ephedrine, and phenylpropanolamine. The combination of MAO inhibitors and these drugs can cause an acute hypertensive episode.

Monoamine oxidase also breaks down tyramine, a chemical present in aged cheese, wines, and other aged foods. Since MAOIs inhibit monoamine oxidase, they decrease the breakdown of tyramine from ingested food, thus increasing the level of tyramine in the body. Excessive tyramine can elevate blood pressure and cause a hypertensive crisis. Patients treated with MAOIs should adhere to recommended dietary modifications that reduce the intake of tyramine.

What about taking MAOIs during pregnancy or while breastfeeding?

The FDA classifies MAO inhibitors in pregnancy category C, which means that there is no established evidence of safe and effective use of MAO inhibitor in pregnant women. Therefore, infant risk cannot be ruled out. It is not known whether MAO inhibitors enter breast milk; however, MAO inhibitors should be avoided in nursing mothers to avoid had to the fetus.

REFERENCE: UpToDate. Monoamine oxidase inhibitors (MAOIs) for treating depressed adults.


Medically Reviewed by a Doctor on 7/2/2014


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index

STAY INFORMED

Get the Latest health and medical information delivered direct to your inbox!