MAOIs (Monoamine Oxidase Inhibitors, MAOI) (cont.)

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What are the side effects of MAOIs?

Since MAOIs work in the brain and affect neurotransmitters, they have many side effects. Side effects of MAOIs are:

MAOIs also carry boxed warnings of suicidal thinking and suicidal behavior in children, adolescents, and young adults.

What are examples of MAOIs available in the US?

Examples of oral MAOIs include:

Selegiline is also available in a topical patch form called Emsam.

What drugs interact with MAOIs?

MAO inhibitors should be avoided with other antidepressants such as paroxetine fluoxetine, amitriptyline, nortriptyline, bupropion; pain medications like methadone, tramadol, and meperidine; dextromethorphan, St. Johns Wort, cyclobenzaprine, and mirtazapine. Such combinations lead to high serotonin levels which may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. These medications should not be used within 14 days of stopping an MAOI.

Medically Reviewed by a Doctor on 3/27/2015

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