mannitol (Osmitrol) (cont.)

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PREPARATIONS: Mannitol intravenous injections are available in following strengths and sizes: 5% and 10% in 1000 ml containers; 15% in 500 ml containers, 20% in 250 ml and 500 ml containers; and 25% in 50 ml flip-top vials.

STORAGE: Store mannitol injections at room temperature between 20 C to 25 C (68 F to 77 F).



  • Prevention of acute renal railure (oliguria): 50 to100 g of mannitol given as 5%, 10%, or 15% solution depending on the patient's fluid requirements.
  • Treatment of oliguria: 100 g administered as a 15 or 20% solution.
  • Reduction of intracranial pressure and brain mass: 0.25 g/kg given every 6 to 8 hours.
  • Reduction of intraocular pressure: 1.5 to 2 g/kg body weight, as 15% to 25% solution administered over 30 to 60 minutes.
  • Adjunctive therapy for intoxications: Adults may receive a 5% to 25% solution for as long as urinary output remains high.

DRUG INTERACTIONS: Mannitol should not be used with tobramycin, because mannitol increases tobramycin levels significantly through an unknown mechanism.

PREGNANCY: There are no adequate studies done on mannitol to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Mannitol enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 10/9/2015

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