mannitol (Osmitrol)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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DOSING:

Adults

  • Prevention of acute renal railure (oliguria): 50 to100 g of mannitol given as 5%, 10%, or 15% solution depending on the patient's fluid requirements.
  • Treatment of oliguria: 100 g administered as a 15 or 20% solution.
  • Reduction of intracranial pressure and brain mass: 0.25 g/kg given every 6 to 8 hours.
  • Reduction of intraocular pressure: 1.5 to 2 g/kg body weight, as 15% to 25% solution administered over 30 to 60 minutes.
  • Adjunctive therapy for intoxications: Adults may receive a 5% to 25% solution for as long as urinary output remains high.

DRUG INTERACTIONS: Mannitol should not be used with tobramycin, because mannitol increases tobramycin levels significantly through an unknown mechanism.

PREGNANCY: There are no adequate studies done on mannitol to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Mannitol enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 10/9/2015

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