mannitol (Osmitrol) (cont.)

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  • Prevention of acute renal railure (oliguria): 50 to100 g of mannitol given as 5%, 10%, or 15% solution depending on the patient's fluid requirements.
  • Treatment of oliguria: 100 g administered as a 15 or 20% solution.
  • Reduction of intracranial pressure and brain mass: 0.25 g/kg given every 6 to 8 hours.
  • Reduction of intraocular pressure: 1.5 to 2 g/kg body weight, as 15% to 25% solution administered over 30 to 60 minutes.
  • Adjunctive therapy for intoxications: Adults may receive a 5% to 25% solution for as long as urinary output remains high.

DRUG INTERACTIONS: Mannitol should not be used with tobramycin, because mannitol increases tobramycin levels significantly through an unknown mechanism.

PREGNANCY: There are no adequate studies done on mannitol to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Mannitol enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

SIDE EFFECTS: Side effects of Mannitol are pulmonary congestion, fluid and electrolyte imbalance, dry mouth, thirst, headache, blurred vision, dizziness, nausea, and chest pain.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 6/30/2014

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