- Prevention of acute renal railure (oliguria): 50 to100 g of mannitol given as 5%, 10%, or 15% solution depending on the patient's fluid requirements.
- Treatment of oliguria: 100 g administered as a 15 or 20% solution.
- Reduction of intracranial pressure and brain mass: 0.25 g/kg given every 6 to 8 hours.
- Reduction of intraocular pressure: 1.5 to 2 g/kg body weight, as 15% to 25% solution administered over 30 to 60 minutes.
- Adjunctive therapy for intoxications: Adults may receive a 5% to 25% solution for as long as urinary output remains high.
DRUG INTERACTIONS: Mannitol should not be used with tobramycin, because mannitol increases tobramycin levels significantly through an unknown mechanism.
PREGNANCY: There are no adequate studies done on mannitol to determine safe and effective use in pregnant women.
NURSING MOTHERS: It is not known whether Mannitol enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information.
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