mannitol (Osmitrol)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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GENERIC NAME: mannitol

BRAND NAME: Osmitrol

DRUG CLASS AND MECHANISM: Mannitol is a naturally occurring substance that causes the body to lose water (diuresis) through osmosis. Mannitol promotes diuresis in kidneys by increasing the concentration of filtrates in the kidney and blocking reabsorption of water by kidney tubules. The FDA approved mannitol in June 1964.

PRESCRIBED FOR: Mannitol is used for diuresis in treatment and prevention of reduced urine production in acute kidney failure. It is also used for reducing intracranial pressure and brain mass in people with swelling in the brain (cerebral edema). It is used for reducing intraocular pressure and irrigation of the urinary bladder to promote urinary excretion of toxic materials.

SIDE EFFECTS: Side effects of Mannitol are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Mannitol intravenous injections are available in following strengths and sizes: 5% and 10% in 1000 ml containers; 15% in 500 ml containers, 20% in 250 ml and 500 ml containers; and 25% in 50 ml flip-top vials.

STORAGE: Store mannitol injections at room temperature between 20 C to 25 C (68 F to 77 F).

Medically Reviewed by a Doctor on 10/9/2015

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