GENERIC NAME: mannitol
BRAND NAME: Osmitrol
DRUG CLASS AND MECHANISM: Mannitol is a naturally occurring substance that causes the body to lose water (diuresis) through osmosis. Mannitol promotes diuresis in kidneys by increasing the concentration of filtrates in the kidney and blocking reabsorption of water by kidney tubules. The FDA approved mannitol in June 1964.
PRESCRIBED FOR: Mannitol is used for diuresis in treatment and prevention of reduced urine production in acute kidney failure. It is also used for reducing intracranial pressure and brain mass in people with swelling in the brain (cerebral edema). It is used for reducing intraocular pressure and irrigation of the urinary bladder to promote urinary excretion of toxic materials.
SIDE EFFECTS: Side effects of Mannitol are:
- pulmonary congestion,
- fluid and electrolyte imbalance,
- dry mouth,
- blurred vision,
- nausea, and
- chest pain.
GENERIC AVAILABLE: Yes
PREPARATIONS: Mannitol intravenous injections are available in following strengths and sizes: 5% and 10% in 1000 ml containers; 15% in 500 ml containers, 20% in 250 ml and 500 ml containers; and 25% in 50 ml flip-top vials.
STORAGE: Store mannitol injections at room temperature between 20 C to 25 C (68 F to 77 F).
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