mannitol (Osmitrol)

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GENERIC NAME: mannitol

BRAND NAME: Osmitrol

DRUG CLASS AND MECHANISM: Mannitol is a naturally occurring substance that causes the body to lose water (diuresis) through osmosis. Mannitol promotes diuresis in kidneys by increasing the concentration of filtrates in the kidney and blocking reabsorption of water by kidney tubules. The FDA approved mannitol in June 1964.



PREPARATIONS: Mannitol intravenous injections are available in following strengths and sizes: 5% and 10% in 1000 ml containers; 15% in 500 ml containers, 20% in 250 ml and 500 ml containers; and 25% in 50 ml flip-top vials.

STORAGE: Store mannitol injections at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Mannitol is used for diuresis in treatment and prevention of reduced urine production in acute kidney failure. It is also used for reducing intracranial pressure and brain mass in people with swelling in the brain (cerebral edema). It is used for reducing intraocular pressure and irrigation of the urinary bladder to promote urinary excretion of toxic materials.

Medically Reviewed by a Doctor on 6/30/2014

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