magnesium sulfate (injection)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

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GENERIC NAME: magnesium sulfate

BRAND NAME: Chloromag

DRUG CLASS AND MECHANISM: Magnesium sulfate is a sterile solution of magnesium sulfate heptahydrate in water for injection. Magnesium sulfate prevents convulsions by blocking transmission between nerves and muscles. It also reduces the amount of t acetylcholine, a chemical that nerves use for communicating with other nerves and tissues.

PRESCRIBED FOR: Magnesium sulfate is prescribed for hypomagnesemia, seizures with pre-eclampsia or eclampsia, and abnormal heart rhythm, Torsades de Pointes.

SIDE EFFECTS: Side effects of magnesium sulfate are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Intramuscular magnesium sulfate available in 500 mg/ml strength, in 2 ml, 10 ml, and 50 ml single-use vials.

Intravenous magnesium sulfate is available in 40mg/ml and 80mg/ml strengths. 40 mg/ml concentration is available in 50 ml, 100 ml, 500 ml, and 1000 ml single-dose, plastic containers. 80 mg/ml concentration is available in 50 ml partial-fill, single-dose, flexible plastic container.

STORAGE: Intramuscular magnesium sulfate injections are stored between 15 C to 30 C (59 F to 86 F). Intravenous magnesium sulfate injections are stored between 20 C to 25 C (68 F to 77 F).

DOSING:

Adults

Hypomagnesemia:

  • Mild: Inject 1 gram intramuscularly (IM) every 6 hours for 4 doses.
  • Severe: 5 grams administered intravenously (IV) over 3 hours.
  • Maintenance: 30-60 mg/kg/day IV.
Medically Reviewed by a Doctor on 3/19/2015
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