- Schizophrenia Slideshow Pictures
- Take the Schizophrenia Quiz
- Physical Symptoms of Depression Slideshow
- What is lurasidone hydrochloride Latuda, and how does it work (mechanism of action)?
- What brand names are available for lurasidone hydrochloride Latuda?
- Is lurasidone hydrochloride Latuda available as a generic drug?
- Do I need a prescription for lurasidone hydrochloride Latuda?
- What are the side effects of lurasidone hydrochloride Latuda?
- What is the dosage for lurasidone hydrochloride Latuda?
- Which drugs or supplements interact with lurasidone hydrochloride Latuda?
- Is lurasidone hydrochloride Latuda safe to take if I'm pregnant or breastfeeding?
- What else should I know about lurasidone hydrochloride Latuda?
What is lurasidone hydrochloride Latuda, and how does it work (mechanism of action)?
Lurasidone (Latuda) belongs to a class of medications known as atypical antipsychotics. Other members of this class include clozapine (Clozaril), risperidone (Risperdal), aripiprazole (Abilify) and ziprasidone (Geodon). Atypical antipsychotics like lurasidone are considered the standard of care for treating schizophrenia. Additionally, in clinical studies lurasidone was shown to be effective in improving mood in many people struggling with bipolar depression. Lurasidone can be taken alone or with either lithium (Lithobid) or valproate (Depakote).
The exact mechanism of action of lurasidone is not known. It may work by blocking receptors for several neurotransmitters (chemicals that nerves use to communicate with each other) in the brain. It binds to dopamine and serotonin type 2 (5-HT2) receptors.
Lurasidone was approved for the treatment of schizophrenia in adults in October, 2010. Almost three years later in July, 2012 the FDA approved lurasidone for the treatment of depressive episodes associated with bipolar I disorder.
What brand names are available for lurasidone hydrochloride Latuda?
Is lurasidone hydrochloride Latuda available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for lurasidone hydrochloride Latuda?
What are the side effects of lurasidone hydrochloride Latuda?
The most common side effects of lurasidone include:
- sleepiness or drowsiness,
- akathesia (restlessness or feeling a need to move around),
- difficulty moving,
- slow movements,
- muscle stiffness,
- tremor, and
Lurasidone may increase the risk of stroke that can lead to death in elderly patients with dementia. It is associated with an increased risk of suicidal thoughts or actions especially in children, teenagers, and young adults within the first few months of treatment. Neuroleptic malignant syndrome or NMS, a rare but serious disorder caused by antipsychotic medicines can occur.
Other side effects include:
- Involuntary movements of the face, tongue, or other body parts called tardive dyskinesia;
- high blood sugar (hyperglycemia);
- increased cholesterol and triglycerides;
- weight gain;
- increases in prolactin levels;
- a drop in white blood cell count;
- a decrease in blood pressure especially when rising too quickly from a sitting or lying position;
- seizures; and
- difficulty swallowing.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.