lurasidone hydrochloride (Latuda)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is lurasidone hydrochloride Latuda, and how does it work (mechanism of action)?

Lurasidone (Latuda) belongs to a class of medications known as atypical antipsychotics. Other members of this class include clozapine (Clozaril), risperidone (Risperdal), aripiprazole (Abilify) and ziprasidone (Geodon). Atypical antipsychotics like lurasidone are considered the standard of care for treating schizophrenia. Additionally, in clinical studies lurasidone was shown to be effective in improving mood in many people struggling with bipolar depression. Lurasidone can be taken alone or with either lithium (Lithobid) or valproate (Depakote).

The exact mechanism of action of lurasidone is not known. It may work by blocking receptors for several neurotransmitters (chemicals that nerves use to communicate with each other) in the brain. It binds to dopamine and serotonin type 2 (5-HT2) receptors.

Lurasidone was approved for the treatment of schizophrenia in adults in October, 2010. Almost three years later in July, 2012 the FDA approved lurasidone for the treatment of depressive episodes associated with bipolar I disorder.

What brand names are available for lurasidone hydrochloride Latuda?


Is lurasidone hydrochloride Latuda available as a generic drug?


Do I need a prescription for lurasidone hydrochloride Latuda?


What are the side effects of lurasidone hydrochloride Latuda?

The most common side effects of lurasidone include:

  • sleepiness or drowsiness,
  • akathesia (restlessness or feeling a need to move around),
  • difficulty moving,
  • slow movements,
  • muscle stiffness,
  • tremor, and
  • nausea.

Lurasidone may increase the risk of stroke that can lead to death in elderly patients with dementia. It is associated with an increased risk of suicidal thoughts or actions especially in children, teenagers, and young adults within the first few months of treatment. Neuroleptic malignant syndrome or NMS, a rare but serious disorder caused by antipsychotic medicines can occur.

Other side effects include:

Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment

Schizophrenia: Symptoms, Types, Causes, Treatment
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