Table of Contents
- Lung cancer facts
- What is lung cancer?
- How common is lung cancer?
- What causes lung cancer?
- What causes lung cancer? (Part 2)
- What causes lung cancer? (Part 3)
- What are the types of lung cancer?
- What are lung cancer symptoms and signs?
- How do health-care professionals diagnose lung cancer?
- How do health-care professionals diagnose lung cancer? (Continued)
- How do health-care professionals determine lung cancer staging?
- What is the treatment for lung cancer?
- What is the treatment for lung cancer? (Part 2)
- What is the treatment for lung cancer? (Part 3)
- What is the prognosis of lung cancer?
- Is it possible to prevent lung cancer?
Treatment of Stage IV Lung Cancer With ALK Rearrangement
Identification of an ALK gene rearrangement in a lung cancer is important for deciding the optimal treatment course. The ALK rearrangement means that drugs that specifically act against the abnormal fusion protein can be used. Three drugs, crizotinib (Xalkori), ceritinib (Zykadia), and alectinib (Alecensa), have been developed to target the activity of the abnormal fusion protein, and additional agents are under development. For patients with advanced or metastatic ALK-positive NSCLC who do not have metastases to the brain, the ALK inhibitor crizotinib is the recommended therapy. Ceritinib or alectinib is typically given if the cancer becomes resistant to crizotinib or if the patient is unable to tolerate crizotinib.
Quick GuideLung Cancer Symptoms, Stages, Treatment
Lung cancer facts
- Lung cancer is the number one cause of cancer deaths in both men and women in the U.S. and worldwide.
- Cigarette smoking is the principal risk factor for development of lung cancer.
- Passive exposure to tobacco smoke also can cause lung cancer.
- The two types of lung cancer, which grow and spread differently, are small cell lung cancers (SCLC) and non-small cell lung cancers (NSCLC).
- The stage of lung cancer refers to the extent to which the cancer has spread in the body.
- Treatment of lung cancer can involve a combination of surgery, chemotherapy, and radiation therapy as well as newer experimental methods.
- The general prognosis of lung cancer is poor because doctors tend not to find the disease until it is at an advanced stage. Five-year survival is around 54% for early stage lung cancer that is localized to the lungs, but only around 4% in advanced, inoperable lung cancer.
- Smoking cessation is the most important measure that can prevent the development of lung cancer. Continue Reading
Amos, C.I., et al. "Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1." Nature Genetics 40.5 (2008): 616-622.
United States. Centers for Disease Control and Prevention. "Lung Cancer." Nov. 6, 2014. <http://www.cdc.gov/cancer/lung/>.
United States. National Cancer Institute. "Lung Cancer." <http://www.cancer.gov/cancertopics/types/lung>.
2. Getty Images/Science Photo Library
3. iStock/ MedicineNet / American Cancer Society
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10. National Cancer Institute / Ytrottier/ iStock
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