lovastatin, Mevacor, Altoprev (cont.)

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PREPARATIONS: Tablets: 10, 20 and 40 mg. Extended release tablets: 10, 20, 40, and 60 mg.

STORAGE: Immediate release tablets should be stored between 5-30 C (41-86 F). Extended release tablets should be stored at room temperature, 20-25 C (68-77 F).

PRESCRIBED FOR: Lovastatin is used for reducing total cholesterol and LDL cholesterol, and triglycerides, and for increasing HDL cholesterol in patients with elevated blood cholesterol levels (hypercholesterolemia). Lovastatin is used for reducing the risk of heart attacks, angina, coronary revascularization procedures in individuals without symptomatic cardiovascular disease, average to moderately elevated cholesterol levels and below average HDL cholesterol levels. It also is used for slowing the progression of coronary atherosclerosis in individuals with coronary heart disease.

DOSING: The dose range for lovastatin is 10-80 mg daily given preferably in the evening when it may be most effective. The usual starting dose is 20 mg once daily, and the maximum dose is 80 mg daily. Blood cholesterol determinations are performed at regular intervals during treatment so that adjustments in dosage can be made.

DRUG INTERACTIONS: Decreased elimination of lovastatin could increase the levels of lovastatin in the body and increase the risk of muscle toxicity from lovastatin. Examples of drugs that decrease elimination of lovastatin include erythromycin (E-Mycin), ketoconazole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), telithromycin (Ketek), cyclosporine (Sandimmune), nefazodone (Serzone), boceprevir (Victrelis), telaprevir (incivek), voriconazole (Vfend), and protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir). They should not be combined with lovastatin.

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