losartan and hydrochlorothiazide, Hyzaar

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Hydrochlorothiazide (HCTZ) is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid. It works by blocking salt and fluid reabsorption in the kidneys, causing an increased amount of urine containing salt (diuresis). The mechanism of its action in lowering high blood pressure is not well understood. The combination of losartan and HCTZ reduces blood pressure better than either drug alone. Losartan increases potassium levels while HCTZ reduces potassium levels; the combination of both drugs has less effect on potassium levels. The FDA approved Hyzaar in April 1995.

PRESCRIBED FOR: Hyzaar is used to treat patients with high blood pressure and for reducing the risk of stroke in patients with high blood pressure and left ventricular hypertrophy.

SIDE EFFECTS: Common side effects of Hyzaar are:

Other important side effects that may be caused by Hyzaar include:

Hyzaar may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries going to the kidneys). Rare cases of rhabdomyolysis (muscle breakdown), hepatitis, ,reduced number of platelets, and pancreatitis have been reported.

Medically Reviewed by a Doctor on 12/31/2014

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