GENERIC NAME: losartan and hydrochlorothiazide
BRAND NAME: Hyzaar
DRUG CLASS AND MECHANISM: Hyzaar is a combination of losartan (Cozaar) and hydrochlorothiazide and is used for treating high blood pressure. Losartan is an oral medication that belongs to a class of drugs called angiotensin receptor blockers (ARBs). Other ARBs include irbesartan (Avapro), valsartan (Diovan), and candesartan (Atacand). Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells surrounding blood vessels. Angiotensin's attachment to the receptors causes the muscles to contract and the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Losartan (more specifically, the chemical formed when the liver converts the inactive losartan into an active chemical) blocks the angiotensin receptor. By blocking the action of angiotensin, losartan relaxes the muscles, dilates blood vessels and thereby reduces blood pressure.
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