losartan, Cozaar (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY: When used in the second or third trimester of pregnancy , ARBs can cause injury and even death to the fetus. Losartan should not be used during pregnancy. When pregnancy is first detected, losartan should be stopped.

NURSING MOTHERS: It is not known whether losartan is excreted in breast milk , but losartan and its active form are excreted in rat milk. Due to the possibility of harm to the nursing infant, if possible, losartan should be discontinued by nursing mothers.

SIDE EFFECTS: In clinical studies the overall incidence of side effects was similar to placebo. Side effects reported included diarrhea, muscle cramps, dizziness, insomnia, and nasal congestion. Losartan also may cause a persistent cough, increase serum potassium, impotence, and angioedema. Losartan may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries going to the kidneys). Rare cases of rhabdomyolysis (muscle breakdown) have been reported.

Reference: FDA Prescribing Information


Last Editorial Review: 2/21/2012



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