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- What is losartan, and how does it work (mechanism of action)?
- What brand names are available for losartan?
- Is losartan available as a generic drug?
- Do I need a prescription for losartan?
- What are the side effects of losartan?
- What is the dosage for losartan?
- Which drugs or supplements interact with losartan?
- Is losartan safe to take if I'm pregnant or breastfeeding?
- What else should I know about losartan?
What is the dosage for losartan?
The starting dose of losartan for adults is 25-50 mg daily. The maximum dose is 100 mg daily. The total daily dose may be divided and administered two doses daily. Losartan may be given with or without food.
The starting dose of losartan for pediatric patients 6 years of age or older is 0.7 mg/kg up to 50 mg once daily. Doses more than 1.4 mg/kg or 100 mg daily have not been evaluated in pediatric patients.
Which drugs or supplements interact with losartan?
Losartan may increase levels of blood potassium (hyperkalemia), which can lead to serious heart problems (arrhythmias). Therefore, concomitant use of other drugs or substances that increase blood-such as potassium-sparing diuretics (for example, spironolactone [Aldactone], triamterene, and amiloride), potassium supplements, or salt substitutes containing potassium may lead to dangerous increases in serum potassium.
Combining losartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
- ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.),
- indomethacin (Indocin, Indocin-SR), and
- naproxen (Anaprox, Naprelan, Naprosyn, Aleve).
Combining ARBs, ACE inhibitors, or aliskiren (Tekturna) increases risk of hypotension (low blood pressure), hyperkalemia, and reduces kidney function compared to each drug used alone and there is no additional benefit on preventing end stage kidney disease or death.
Aliskiren and losartan should not be combined in patients with diabetes or with renal impairment.
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