lorazepam, Ativan (cont.)

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Medical and Pharmacy Editor:

PREPARATIONS: Tablets: 0.5, 1, and 2 mg. Oral solution: 2 mg/ml. Injection: 2 mg/ml and 4 mg/ml

DRUG INTERACTIONS: Lorazepam and all benzodiazepines accentuate the effects of other drugs that slow the brain's processes such as alcohol, barbiturates, narcotics, and tranquilizers, and the combination of lorazepam and these drugs may lead to excessive sedation. There have been cases of marked sedation when lorazepam was given to patients taking the tranquilizer loxapine (Loxitane); it is unclear if there is a drug interaction, but caution should be used if lorazepam and loxapine are used together.

PREGNANCY AND BREASTFEEDING SAFETY: Lorazepam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Lorazepam is best avoided if at all possible in the first trimester and probably throughout pregnancy.

Lorazepam is excreted in human milk and should be avoided during pregnancy.

STORAGE: Tablets should be kept at room temperature 15 C to 30 C (59 F to 86 F). Oral solutions should be refrigerated at 2 C to 8 C (36 F to 46 F). Injectable solutions should be refrigerated.

Medically Reviewed by a Doctor on 3/30/2016


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