SIDE EFFECTS: Side effects of loratadine/pseudoephedrine include:
- stimulation of the nervous system leading to nervousness,
- hallucinations, and
- convulsions (seizures).
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets containing 5 mg loratadine and 120 mg pseudoephedrine (12 hour formulation) and tablets containing 10 mg loratadine and 240 mg pseudoephedrine (24 hour formulation) are available.
STORAGE: Tablets should be stored at 15 C to 30 C (59 F to 86 F).
- Loratadine/pseudoephedrine may be taken with or without food.
- It must be used cautiously in patients with heart (coronary artery) disease and angina (because pseudoephedrine can stimulate the heart) as well as in patients with diabetes (because there is a small chance that pseudoephedrine can raise the level of blood sugar).
- The dose for children older than 12 years and adults is 1 tablet every 12 hours of immediate release tablets or 1 tablet every 24 hours for extended release tablets.
- Loratadine/pseudoephedrine should not be taken at the same time as or within 14 days of monoamine oxidase inhibitors (MAOIs).
- Erythromycin, cimetidine (Tagamet), itraconazole (Sporanox), and ketoconazole (Nizoral) increase the blood concentration of loratadine by inhibiting the elimination of loratadine. This may result in increased adverse events from loratadine.
- St. John's wort, carbamazepine, and rifampin reduce blood levels of loratadine.
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