DOSING: The recommended dose for adults is 200-400 mg every 12 hours.
DRUG INTERACTIONS: Probenecid (Benemid) may increase the concentration of loracarbef in the blood by decreasing excretion of loracarbef by the kidney. This interaction is sometimes used to enhance the effect of cephalosporins.
PREGNANCY: Safe use during pregnancy has not been established.
NURSING MOTHERS: Safe use in nursing mothers has not been established.
SIDE EFFECTS: Loracarbef is generally well tolerated, and side effects are usually transient. More common side effects include nausea, abdominal pain, vomiting, skin rash, abnormal liver tests, vaginitis, itching, headaches, and dizziness.
Loracarbef should be avoided by patients with a known allergy to other cephalosporin antibiotics. Since loracarbef is chemically related to penicillin, an occasional patient can have an allergic reaction (sometimes even life threatening anaphylaxis) to both medications. Treatment with loracarbef and other antibiotics can alter the normal bacteria flora of the colon and permit overgrowth of the bacterium, Clostridium difficile, in the colon. This may lead to inflammation of the colon known as C. difficile or pseudo-membranous colitis. Patients who develop pseudo-membranous colitis as a result of antibiotic treatment can experience diarrhea, abdominal pain, fever, and sometimes even shock.
Reference: FDA Prescribing Information
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