Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
BRAND NAME: (Lorabid: This brand no longer is available in the U.S.)
DRUG CLASS AND MECHANISM: Loracarbef is a synthetic (man-made) oral
antibiotic in the cephalosporin family of antibiotics. The cephalosporin family
includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef),
cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable antibiotics. Like
other cephalosporins, loracarbef stops bacteria from multiplying by preventing
bacteria from forming the walls that surround them. The walls are necessary to
protect bacteria from their environment and to keep the contents of the
bacterial cell together; bacteria cannot survive without a cell wall. Loracarbef
is effective against a wide variety of bacteria such as Staphylococcus aureus,
Streptococcus pneumoniae, Streptococcus pyogenes,
Haemophilus influenzae,
E.
coli, and many others. Loracarbef was approved in December 1991.
PRESCRIPTION: Yes
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 200 and 400 mg. Suspension: 100 and 200 mg/5 ml.
STORAGE: Tablets and oral suspension may be stored at room temperature, 59°
to 86°F (15° to 30°C) in a tightly closed container.
DOSING: The recommended dose for adults is 200-400 mg every 12 hours.
DRUG INTERACTIONS:Probenecid
(Benemid) may increase the concentration of loracarbef in
the blood by decreasing excretion of loracarbef by the kidney. This interaction
is sometimes used to enhance the effect of cephalosporins.
PREGNANCY: Safe use during
pregnancy has not been established.
NURSING MOTHERS: Safe use in
nursing mothers has not been established.
Loracarbef should be avoided by patients with a known allergy to other
cephalosporin antibiotics. Since loracarbef is chemically related to penicillin,
an occasional patient can have an allergic reaction (sometimes even life
threatening anaphylaxis) to both medications. Treatment with loracarbef and
other antibiotics can alter the normal bacteria flora of the colon and permit
overgrowth of the bacterium, Clostridium difficile, in the colon. This may lead
to inflammation of the colon known as C. difficile or pseudo-membranous colitis.
Patients who develop pseudo-membranous colitis as a result of antibiotic
treatment can experience diarrhea, abdominal pain, fever, and sometimes even
shock.
Urinary tract infection (UTI) is an infection of the kidney, ureter, bladder, and/or urethra. Not
everyone with a UTI has symptoms. Common symptoms include a frequent urge to
urinate and a painful, burning when urinating.
Pneumonia is inflammation of one or both lungs with consolidation. Pneumonia is frequently but not always due to infection. The infection may be bacterial, viral, fungal or parasitic. Symptoms may include fever, chills, cough with sputum production, chest pain, and shortness of breath.
Most sore throats are caused by viruses or mechanical causes (such as mouth breathing) and can be treated successfully at home. However, a person should be seen by a health care professional if they have a sore throat that has a rapid onset, and is associated with a fever or tenderness of the front of the neck; a sore throat that causes the person to have difficulty swallowing (not just pain swallowing) or breathing; or if a sore throat lasts for more than a week.
Staphylococcus or Staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a Staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
Strep throat is a sore throat caused by a bacterium called streptococcus (strep) that can be treated through antibiotics. Common symptoms of strep throat include pinkeye, runny nose, skin rash, cough, hoarseness, diarrhea and more. Complications of untreated strep throat include middle ear infections, meningitis, pneumonia, rheumatic fever, and more.
Sinus infection (sinusitis) signs and symptoms include headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
Bronchitis is a disease of the respiratory system in which the bronchial passages become inflamed. There are two types of bronchitis, acute and chronic. Symptoms of acute bronchitis include frequent cough with mucus, lack of energy, wheezing, and possible fever. Treatment may require medication such as bronchial inhalers and predinsone. Supportive treatment is focused on relieving the symptoms with fever reducers, cough suppressants, and rest. Treatment may be more aggressive in patients with pre-existing conditions such as empyema, COPD, or cigarette smoking.
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is infection, which inflames the vocal cords. Symptoms may vary from degree of laryngitis and age of the patient. Common symptoms include croup, hoarse cough, fever, cold, runny nose, dry cough, and loss of voice. Chronic laryngitis generally lasts more than three weeks. Causes other than infection include smoking, excess coughing, GERD, and more. Treatment depends on the cause of laryngitis.
It is thought that the tonsils and adenoids assist the body in fighting incoming bacteria and viruses by helping the body form antibodies. This is thought to be important only during the first year of life. Acute tonsillitis, strep throat, mononucleosis (mono), chronic tonsillitis, peritonsillar abscess, and hypertrophic tonsils and adenoids are all common problems involving the tonsils and adenoids. Treatment of tonsillitis and adenoids include antibiotics and other medications depending on the cause. In some cases, a tonsillectomy or adenoidectomy (the removal of the tonsils or adenoids) may be necessary.
Influenza (flu) is a respiratory illness caused by a virus. Flu symptoms include fever, cough, sore throat, runny nose, headache, fatigue, and muscle aches. The flu may be prevented with an annual influenza vaccination.
Middle ear infection or inflammation (otitis media) is inflammation fo the middle ear. There are two types of otitis media, acute and chronic. Acute otitis media is generally short in duration, and chronic otitis media generally lasts several weeks. Seventy-five percent of children in the U.S. suffer from otitis media at some point. Treatment depends upon the type (chronic or acute).
There are many types of E. Coli (Escherichia coli ). Pathogenic E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Group A streptococcal infections are caused by group A streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
Drug resistance (antimicrobial resistance) is the ability of bacteria, fungi, parasites, and viruses to grow, even in the presence of a drug that would normally kill it (or limit it's growth). Drug resistance is a growing problem, particularly for infections such as MRSA, VRE (vancomycin-resistant enterococci), tuberculosis, HIV, STDs, gonorrhea, flu, pneumonia, malaria, E. coli, salmonella, Campylobacter, which causes diarrhea and gastroenteritis. Learn how to protect yourself from resistance to drugs.
While many people use the terms sore throat, tonsillitis, and strep throat
interchangeably, there are significant clinical differences between these
conditions. Understanding the differences can give patients a better idea of how
and when to be concerned and when to seek advice from a physician.
Strep throat is only one of many possible causes of throat infection and sore
throat. While strep throat is most common in children and adolescents, it can
affect people of all ages.
What causes sore throat?
Sore throat has many causes. The most common causes of sore throat are
infections of the throat and the surrounding structures. Any inflammation or
infection of the pharynx, tonsils, esophagus (the food pipe), or larynx (the top
opening part of the windpipe) may cause sore throat.
What are the tonsils and tonsillitis?
The tonsils are red, oval clumps of tissue locat...
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