lopinavir and ritonavir, Kaletra (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Kaletra interacts with many drugs. Some of the important interactions are mentioned below. Patients should consult their healthcare provider before combining any drug with Kaletra.

Kaletra should not be used together with amiodarone (Cordarone), quinidine (Quinaglute, Cardioquin), triazolam (Halcion), midazolam (Versed), pimozide (Orap), ergotamine derivatives (for example, Ergostat), propafenone (Rythmol) and flecainide (Tambocor) because Kaletra increases the levels of these drugs in the body and as a result may lead to serious adverse effects of these drugs.

Kaletra may also prevent the break down of lovastatin (Mevacor), simvastatin (Zocor), rosuvastatin (Crestor) and atorvastatin (Lipitor), causing their levels in the body to rise. This may increase the occurrence of muscle breakdown (rhabdomyolysis), which is a side effect of these drugs. Therefore, lovastatin and simvastatin should not be combined with Kaletra; the dose of rosuvastatin should not exceed 10 mg/day and the lowest dose of atorvastatin should be used. The blood concentration of rifabutin (Mycobutin) and sildenafil (Viagra) can be increased by Kaletra. Therefore, the doses of rifabutin and sildenafil should be reduced.

The oral solution contains alcohol, which causes severe side effects when combined with metronidazole (Flagyl) or disulfiram (Antabuse).

Kaletra can reduce the effectiveness of oral contraceptives.

Rifampin (Rifadin), St. John's wort, efavirenz (Sustiva) and nevirapine (Viramune) decrease the blood levels of Kaletra and this can reduce the effectiveness of Kaletra.

Medically Reviewed by a Doctor on 7/9/2015


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index