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- What is lopinavir and ritonavir, and how does it work (mechanism of action)?
- What brand names are available for lopinavir and ritonavir?
- Is lopinavir and ritonavir available as a generic drug?
- Do I need a prescription for lopinavir and ritonavir?
- What are the side effects of lopinavir and ritonavir?
- What is the dosage for lopinavir and ritonavir?
- Which drugs or supplements interact with lopinavir and ritonavir?
- Is lopinavir and ritonavir safe to take if I'm pregnant or breastfeeding?
- What else should I know about lopinavir and ritonavir?
What is the dosage for lopinavir and ritonavir?
Kaletra tablets may be administered with or without food. Oral solution and capsules should be administered with food. There are several dosing regimens depending on the formulation used, age of the patient, previous exposure to lopinavir, or use of other drugs. Here are some examples.
- Therapy-naive adult patients: 400/100 tablets (3 capsules) twice daily or 800/200 (6 capsules) once daily; Oral solution, 5 mL twice daily or 10 mL once daily with food.
- Therapy-experienced adult patients: 200/50 tablets, two twice daily or 3 capsules twice daily; Oral solution 5 mL twice daily. Once daily administration of Kaletra is not recommended.
- Children between 6 months and 18 years of age: The recommended dose is 230/57.5/m2 of the oral solution given twice daily and not to exceed the recommended adult dose. Kaletra should not be administered once daily in patients less than 18 years of age.
- Children between 14 days and 6 months of age: The recommended dose is 16/4/kg or 300/75/m2 of the oral solution given twice daily.
- In combination with efavirenz (Sustiva), nevirapine (Viramune), fosamprenavir (Lexiva) or nelfinavir (Viracept): Once daily administration is not recommended when combined with efavirenz, nevirapine, fosamprenavir or nelfinavir. For adults, the recommended dose is two 200/50 tablets and one 100/25 tablet twice daily; Oral solution, 6.5 mL twice daily. For children, the recommended dose is 300/75/m2 not to exceed the adult dose.
Which drugs or supplements interact with lopinavir and ritonavir?
Kaletra interacts with many drugs. Some of the important interactions are mentioned below. Patients should consult their healthcare provider before combining any drug with Kaletra.
Kaletra should not be used together with amiodarone (Cordarone), quinidine (Quinaglute, Cardioquin), triazolam (Halcion), midazolam (Versed), pimozide (Orap), ergotamine derivatives (for example, Ergostat), propafenone (Rythmol) and flecainide (Tambocor) because Kaletra increases the levels of these drugs in the body and as a result may lead to serious adverse effects of these drugs.
Kaletra may also prevent the break down of lovastatin (Mevacor), simvastatin (Zocor), rosuvastatin (Crestor) and atorvastatin (Lipitor), causing their levels in the body to rise. This may increase the occurrence of muscle breakdown (rhabdomyolysis), which is a side effect of these drugs. Therefore, lovastatin and simvastatin should not be combined with Kaletra; the dose of rosuvastatin should not exceed 10 mg/day and the lowest dose of atorvastatin should be used. The blood concentration of rifabutin (Mycobutin) and sildenafil (Viagra) can be increased by Kaletra. Therefore, the doses of rifabutin and sildenafil should be reduced.
Kaletra can reduce the effectiveness of oral contraceptives.
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