lopinavir and ritonavir, Kaletra (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

GENERIC AVAILABLE: No

PRESCRIPTION: Yes

PREPARATIONS: Tablets (mg lopinavir/mg ritonavir): 100/25 and 200/50. Oral solution: 80/20 per mL. Capsules: 133/33.3.

STORAGE: Capsules and solution should be refrigerated at 2 C to 8 C (36 F to 46 F). If stored at room temperature, the capsules and solution should be used within 2 months. Tablets should be stored at 15 C to30 C (59 F to 86 F).

PRESCRIBED FOR: Kaletra is used for the treatment of HIV infection.

DOSING: Kaletra tablets may be administered with or without food. Oral solution and capsules should be administered with food. There are several dosing regimens depending on the formulation used, age of the patient, previous exposure to lopinavir, or use of other drugs. Here are some examples.

  • Therapy-naive adult patients: 400/100 tablets (3 capsules) twice daily or 800/200 (6 capsules) once daily; Oral solution, 5 mL twice daily or 10 mL once daily with food.
  • Therapy-experienced adult patients: 200/50 tablets, two twice daily or 3 capsules twice daily; Oral solution 5 mL twice daily. Once daily administration of Kaletra is not recommended.
  • Children between 6 months and 18 years of age: The recommended dose is 230/57.5/m2 of the oral solution given twice daily and not to exceed the recommended adult dose. Kaletra should not be administered once daily in patients less than 18 years of age.
  • Children between 14 days and 6 months of age: The recommended dose is 16/4/kg or 300/75/m2 of the oral solution given twice daily.
  • In combination with efavirenz (Sustiva), nevirapine (Viramune), fosamprenavir (Lexiva) or nelfinavir (Viracept): Once daily administration is not recommended when combined with efavirenz, nevirapine, fosamprenavir or nelfinavir. For adults, the recommended dose is two 200/50 tablets and one 100/25 tablet twice daily; Oral solution, 6.5 mL twice daily. For children, the recommended dose is 300/75/m2 not to exceed the adult dose.

DRUG INTERACTIONS: Kaletra interacts with many drugs. Some of the important interactions are mentioned below. Patients should consult their healthcare provider before combining any drug with Kaletra.

Kaletra should not be used together with amiodarone (Cordarone), quinidine (Quinaglute, Cardioquin), triazolam (Halcion), midazolam (Versed), pimozide (Orap), ergotamine derivatives (for example, Ergostat), propafenone (Rythmol) and flecainide (Tambocor) because Kaletra increases the levels of these drugs in the body and as a result may lead to serious adverse effects of these drugs.

Medically Reviewed by a Doctor on 3/6/2013


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