Table of Contents
- Liver Disease Facts
- What is liver disease?
- What is liver disease? (Continued)
- What are the causes of liver disease (alcohol and cirrhosis)?
- What are the causes of liver disease (drug-induced liver disease)?
- What are the causes of liver disease (hepatitis and others)?
- What are the causes of liver disease (cancer and others)?
- What are the risk factors for liver disease?
- What are the symptoms of liver disease?
- When to seek medical care for liver disease
- How is liver disease diagnosed?
- What is the treatment for liver disease?
- What are the complications of liver disease?
- Can liver disease be prevented?
- What is the outlook for a patient with liver disease?
What is liver disease?
Liver disease is any disturbance of liver function that causes illness. The liver is responsible for many critical functions within the body and should it become diseased or injured, the loss of those functions can cause significant damage to the body. Liver disease is also referred to as hepatic disease.
Liver disease is a broad term that covers all the potential problems that cause the liver to fail to perform its designated functions. Usually, more than 75% or three quarters of liver tissue needs to be affected before a decrease in function occurs.
The liver is the largest solid organ in the body; and is also considered a gland because among its many functions, it makes and secretes bile. The liver is located in the upper right portion of the abdomen protected by the rib cage. It has two main lobes that are made up of tiny lobules. The liver cells have two different sources of blood supply. The hepatic artery supplies oxygen rich blood that is pumped from the heart, while the portal vein supplies nutrients from the intestine and the spleen.
Normally, veins return blood from the body to the heart, but the portal vein allows nutrients and chemicals from the digestive tract to enter the liver for processing and filtering prior to entering the general circulation. The portal vein also efficiently delivers the chemicals and proteins that liver cells need to produce the proteins, cholesterol, and glycogen required for normal body activities.
Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.
National Digestive Diseases Information Clearinghouse, National Institute of Diabetes and Digestive and Kidney Diseases. "Liver."
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7.Ed Uthman, MD
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