Table of Contents
- What are the basic functions of the liver?
- What are common liver blood function tests?
- What are the aminotransferases enzymes (ALT, AST)?
- Normally, where are AST and ALT (aminotransferase enzymes)?
- What are normal levels of AST and ALT?
- What do high (elevated) liver tests (AST and ALT) mean?
- Do AST and ALT test results indicate liver function?
- What blood tests are done to detect liver function?
- What blood tests are done to detect liver function? (Continued)
- What are some common reasons for abnormal liver tests?
- What medications can cause increased liver enzyme tests (AST and ALT) levels?
- What medications can cause increased liver enzyme tests (AST and ALT)? (continued)
- What conditions can cause very high AST or ALT levels?
- What are some of the less common causes of elevated liver blood and function tests?
- What are some of the less common causes of elevated liver blood tests? (continued)
- How are healthy people evaluated for mild to moderate rises in AST/ALT levels?
- How are healthy people evaluated for mild to moderate rises in AST/ALT levels? (continued)
- How are a person's liver blood values monitored?
- What other liver enzymes cause medical problems?
Normally, where are AST and ALT (aminotransferase enzymes)?
AST (SGOT) is normally found in a variety of tissues including liver, heart, muscle, kidney, and the brain. It is released into the serum when any one of these tissues is damaged. For example, AST level in serum is elevated in heart attacks or with muscle injury. It is therefore, not a highly specific indicator of liver injury as its elevation can occur as a result of other injured tissues.
ALT (SGPT) is, by contrast, normally found largely in the liver. This is not to say that it is exclusively located in the liver, but that is where it is most concentrated. It is released into the bloodstream as the result of liver injury. Thus, it serves as a fairly specific indicator of liver status.
What are normal levels of AST and ALT?
- The normal range of values for AST (SGOT) is about 5 to 40 units per liter of serum (the liquid part of the blood).
- The normal range of values for ALT (SGPT) is about 7 to 56 units per liter of serum.
However, the ranges of AST and ALT numbers may differ slightly depending on the technique and protocols used by different laboratories worldwide. However, normal reference ranges are routinely provided by each laboratory and printed with each patient's individual report.
Brailita, D. M. "Amebic Hepatic Abscesses Workup." Medscape. Udpated Apr 15, 2015.
Sears, D. MD. "Fatty Liver." Medscape. Updated Nov 30, 2015.
Sood, G. "Acute Liver failure workup." Medscape. Updated Feb 04, 2016.
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