lithium, Lithobid

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is lithium, and how does it work (mechanism of action)?

Lithium is used for the treatment of manic/depressive (bipolar) and depressive disorders. Lithium is a positively charged element or particle that is similar to sodium and potassium. It interferes at several places inside cells and on the cell surface with other positively charged atoms such as sodium, potassium, calcium, and magnesium which are important in many cellular functions.

Lithium interferes with the production and uptake of chemical messengers by which nerves communicate with each other (neurotransmitters). Lithium also affects the concentrations of tryptophan and serotonin in the brain. In addition, lithium increases the production of white blood cells in the bone marrow. Lithium's effects usually begin within 1 week of starting treatment, and the full effect is seen by 2 to 3 weeks.

Lithium has been used since the 1950's. The FDA approved lithium carbonate, the most common lithium preparation in 1970.

What brand names are available for lithium?

Lithobid

Is lithium available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for lithium?

Yes

What are the uses for lithium?

What are the side effects of lithium?

The most common side effects that can occur in persons taking lithium are:

Many of the gastrointestinal side effects (nausea, taste alterations, diarrhea) often disappear with continued therapy. Additionally, they may be less common if lithium is taken in divided doses with meals. If diarrhea or excessive urination lead to dehydration, lithium toxicity is possible. Lithium also can cause changes in the electrocardiogram (EKG, ECG), low blood pressure, and decreased heart rate.

Medically Reviewed by a Doctor on 6/17/2016

Quick GuideBipolar Disorder: Symptoms, Testing for Bipolar Depression

Bipolar Disorder: Symptoms, Testing for Bipolar Depression
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