lisdexamfetamine, Vyvanse (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PREGNANCY: There are no adequate studies of lisdexamfetamine in pregnant women. Amphetamines may cause premature delivery, low birth weight, and withdrawal symptoms in infants born to mothers who are dependent on amphetamines.
NURSING MOTHERS: Amphetamines are excreted in breast milk. Mothers taking amphetamines should not breastfeed.
Lisdexamfetamine may cause blurred vision, growth retardation in children, and seizures in patients with a history of seizures. Increased blood pressure, sudden death in patients with heart problems, strokes, and heart attacks have been associated with lisdexamfetamine. Patients may experience new or worsening of psychiatric symptoms (for example, manic episodes, hearing voices, hallucinations) or worsening of aggressive behavior or hostility.
Lisdexamfetamine like other amphetamines may be abused. Amphetamines have been associated with tolerance, psychological dependence, and social disability. Stopping amphetamines suddenly may cause a withdrawal syndrome that includes extreme fatigue and mental depression. Therefore, there use should be discontinued by slowly reducing the dose.
Priapism defined as painful and nonpainful penile erection lasting more than 4 hours, have been reported in pediatric and adult patients treated with stimulants. The erection usually resolves when the drug is stopped. Prompt medical attention is required in the event of suspected priapism.
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 2/4/2014
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