lisdexamfetamine, Vyvanse (cont.)

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DRUG INTERACTIONS: Monoamine oxidase inhibitor (MAOIs) antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl) and procarbazine (Matulane), slow the elimination of amphetamines in the body. This increases the concentration of amphetamines and their effect. This can cause serious elevations in blood pressure (hypertensive crisis) with headaches, other signs of hypertensive crisis, and even fatal reactions. Lisdexamfetamine should not be administered until 14 days after MAOIs have been discontinued in order to allow the effects of the MAOIs to dissipate.

Amphetamines increase the effect of norepinephrine. Combining both drugs may lead to serious cardiovascular toxicity.

PREGNANCY: There are no adequate studies of lisdexamfetamine in pregnant women. Amphetamines may cause premature delivery, low birth weight, and withdrawal symptoms in infants born to mothers who are dependent on amphetamines.

NURSING MOTHERS: Amphetamines are excreted in breast milk. Mothers taking amphetamines should not breastfeed.

SIDE EFFECTS: Common side effects of lisdexamfetamine include upper abdominal pain, nausea, dry mouth, dizziness, weight loss, trouble sleeping, irritability, decreased appetite, and vomiting.

Lisdexamfetamine may cause blurred vision, growth retardation in children, and seizures in patients with a history of seizures. Increased blood pressure, sudden death in patients with heart problems, strokes, and heart attacks have been associated with lisdexamfetamine. Patients may experience new or worsening of psychiatric symptoms (for example, manic episodes, hearing voices, hallucinations) or worsening of aggressive behavior or hostility.

Medically Reviewed by a Doctor on 2/4/2014


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