Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: lisdexamfetamine
BRAND NAME: Vyvanse
DRUG CLASS AND MECHANISM: Lisdexamfetamine is an oral drug used for increasing attention and decreasing impulsiveness and hyperactivity in patients with attention deficit hyperactivity disorder (ADHD). Lisdexamfetamine is a prodrug; after administration it is converted to dextroamphetamine (Adderall) in the intestines and/or liver. The dextroamphetamine, an amphetamine and stimulant for the brain, is responsible for the effect of lisdexamfetamine in ADHD. The mechanism of action of dextroamphetamine in ADHD is unknown, but scientists believe that they may stimulate the nervous system by increasing the release or reducing the inactivation of norepinephrine and dopamine in the brain. Norepinephrine and dopamine are chemicals (neurotransmitters) that nerves use for communicating with each other. The net effect of amphetamines is an increase in the effects of dopamine and norepinephrine. The FDA approved lisdexamfetamine in February 2007.
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 20, 30, 40, 50, 60, and 70 mg
STORAGE: Lisdexamfetamine should be stored at room temperature, 15 C to 30 C (59 F to 86 F), and protected from light.
PRESCRIBED FOR: Lisdexamfetamine is used for the treatment of attention deficit hyperactivity disorder (ADHD).
DOSING: The recommended dose of lisdexamfetamine for adults and pediatric patients ages (6-12) is 30 mg once daily in the morning. Doses may be increased by 10-20 mg/day at weekly intervals. The maximum dose is 70 mg daily. Lisdexamfetamine should not be administered in the afternoon because it may cause insomnia. Capsules may be swallowed whole or the contents may be dissolved in a glass of water.
Medically Reviewed by a Doctor on 2/4/2014
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