GENERIC NAME: liraglutide
BRAND NAME: Victoza
GENERIC AVAILABLE: No
- Victoza is used with diet and exercise to improve control of blood sugar in adults with type 2 diabetes.
- Victoza should not be used for treating diabetic ketoacidosis or type 1 diabetes and should not be used as the first agent for treating diabetes after failure of diet and exercise.
WARNING (BLACK BOX WARNING):
- Victoza causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors in rats and mice. It is unknown whether Victoza may also cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.
- Victoza should not be used by patients with a personal or family history of MTC and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients should learn about the potential risk for MTC and symptoms of thyroid tumors (for example, a mass in the neck, dysphagia, dyspnea, persistent hoarseness).
- The value of monitoring calcitonin levels in blood or using thyroid ultrasound for early detection of MTC in patients treated with Victoza is uncertain.
- The most common side effects of Victoza are
- Combining Victoza with insulin or drugs that stimulate release of insulin (for example, glyburide) may increase the occurrence of low blood sugar (hypoglycemia). The dose of insulin or the insulin release stimulating drug should be reduced.
- There have been reports of acute pancreatitis associated with the use of Victoza. Patients developing severe, persistent abdominal pain that might be caused by pancreatitis, should seek prompt medical attention. If pancreatitis is suspected, Victoza should be discontinued and not started again until the presence of pancreatitis has been excluded.
- Victoza can cause thyroid tumors that occur more frequently at higher doses and with longer duration of treatment. Since Victoza is a synthetic protein patients may develop antibodies to Victoza. Victoza antibodies may reduce the effectiveness of Victoza.
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