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linezolid - oral, Zyvox (cont.)

PRECAUTIONS: Before taking linezolid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, blood disorders (e.g., low blood counts), certain tumor or related conditions (e.g., pheochromocytoma, carcinoid syndrome), untreated overactive thyroid disease (hyperthyroidism), seizure.This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at a greater risk for side effects while using this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: atomoxetine, bethanidine, bupropion, buspirone, carbamazepine, certain antihistamines (azatadine, carbetapentane, chlorpheniramine), dextromethorphan, certain eye drops (apraclonidine, brimonidine), herbal products (e.g., ephedra/ma huang), methyldopa, certain narcotic pain relievers (fentanyl, meperidine), papaverine, drugs for Parkinson's disease (such as entacapone, tolcapone), reboxetine, SSRI antidepressants (e.g., fluoxetine, citalopram), sympathomimetics (e.g., ephedrine, methylphenidate), tetrabenazine, tramadol, tricyclic antidepressants (e.g., amitriptyline, doxepin), "triptans" (e.g., sumatriptan, zolmitriptan), weight loss drugs (sch as sibutramine).Avoid taking other MAO inhibitors (e.g., furazolidone, isocarboxazid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting linezolid.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: bethanidine, indoramin, inhaled bronchodilators (e.g., albuterol, salmeterol), levodopa, other drugs which depress the bone marrow (e.g., cancer chemotherapy), other herbals (such as ginseng, tryptophan).Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Avoid these products while taking this medication. Ask your pharmacist for additional information.Limit your tyramine intake while using this medication and for 2 days after stopping treatment. Also avoid foods or drinks with high tyramine content during use because the combination may cause a serious rise in your blood pressure.Foods high in tyramine include those that may change as a result of aging, fermentation, pickling, or smoking. The tyramine content of any protein-rich food (meats, fish and dairy products) may increase if stored for long periods or improperly refrigerated. Some foods high in tyramine include aged cheeses (0 to 15 milligrams per ounce); fermented or air-dried meats (0.1 to 8 milligrams per ounce); sauerkraut (8 milligrams per 8 ounces); soy sauce (5 milligrams per 1 teaspoon); tap beers (4 milligrams per 12 ounces); red wines (0 to 6 milligrams per 8 ounces). Total intake of tyramine should be less than 100 milligrams per meal.Tell your doctor or pharmacist immediately if you notice symptoms of severe high blood pressure such as fast/pounding heartbeat, vomiting, sweating, headache, chest pain, sudden vision changes, weakness on one side of the body, or slurred speech.Contact your healthcare professional (e.g., doctor, pharmacist or dietician) for more information, including recommendations for your diet.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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