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- What is linezolid-oral tablets, and how does it work (mechanism of action)?
- What brand names are available for linezolid-oral tablets?
- Is linezolid-oral tablets available as a generic drug?
- Do I need a prescription for linezolid-oral tablets?
- What are the uses for linezolid-oral tablets?
- What are the side effects of linezolid-oral tablets?
- What is the dosage for linezolid-oral tablets?
- Which drugs or supplements interact with linezolid-oral tablets?
- Is linezolid-oral tablets safe to take if I'm pregnant or breastfeeding?
- What else should I know about linezolid-oral tablets?
What is the dosage for linezolid-oral tablets?
- The recommended adult dose for treating pneumonia or complicated skin and skin structure infections is 600 mg orally or by intravenous infusion every 12 hours for 10 to 14 days.
- Uncomplicated skin and skin structure infections are treated with 400 to 600 mg orally every 12 hours for 10 to 14 days.
- The dose for vancomycin-resistant Enterococcus faecium infections is 600 mg orally or by intravenous infusion every 12 hours for 14 to 28 days.
Which drugs or supplements interact with linezolid-oral tablets?
- Linezoild is a monoamine oxidase inhibitor (MAOI). This means that linezolid blocks the breakdown of compounds that are normally broken down my monoamine oxidase enzymes. This increases the levels of these compounds in the body and can increase the risk of side effects. Linezolid should not be used by patients taking monoamine oxidase inhibitors (MAOI) or within two weeks of taking an MAOI.
- Linezolid should not be combined with antidepressants such as paroxetine (Paxil), fluoxetine (Prozac), amitriptyline, nortriptyline, bupropion (Wellbutrin, Zyban); pain medications like methadone, tramadol (Ultram), and meperidine (Demerol); dextromethorphan, St. John's Wort, cyclobenzaprine, and mirtazapine (Remeron). Such combinations lead to high serotonin levels which may cause confusion, high blood pressure, tremor, hyperactivity, coma, and death.
- Linezolid should not be combined with pseudoephedrine, phenylephrine, ephedrine, and phenylpropanolamine. The combination of linezolid and these drugs can cause an acute hypertensive episode.
- Monoamine oxidase also breaks down tyramine, a chemical present in aged cheese, wines, and other aged foods. Since linezolid inhibits monoamine oxidase, it decreases the breakdown of tyramine from ingested food, thus increasing the level of tyramine in the body. Excessive tyramine can elevate blood pressure and cause a hypertensive crisis. Patients treated with MAOIs and lInezolid should adhere to recommended dietary modifications that reduce the intake of tyramine.
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