linezolid - injection, Zyvox (cont.)
PRECAUTIONS: Before using linezolid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, blood disorders (e.g., low blood counts), certain tumor or related conditions (e.g., pheochromocytoma, carcinoid syndrome), untreated overactive thyroid disease (hyperthyroidism), seizure.This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at a greater risk for side effects while using this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: atomoxetine, bethanidine, bupropion, carbamazepine, certain antihistamines (azatadine, carbetapentane, chlorpheniramine), certain eye drops (apraclonidine, brimonidine), herbal products (e.g., ephedra/ma huang, ginseng, tryptophan), indoramin, levodopa, methyldopa, certain narcotic pain relievers (fentanyl, meperidine), papaverine, drugs for Parkinson's disease (such as entacapone, tolcapone), rifampin, sympathomimetics (e.g., ephedrine, methylphenidate), tetrabenazine, other drugs which depress the bone marrow (e.g., cancer chemotherapy).Avoid taking other MAO inhibitors (isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication.Before taking linezolid, report the use of other drugs that increase serotonin, such as buspirone, dextromethorphan, lithium, St. John's wort, sibutramine, street drugs such as MDMA/"ecstasy," tramadol, tryptophan, "triptans" used to treat migraine headaches (such as eletriptan, sumatriptan), antidepressants (including mirtazapine, trazodone, vilazodone, SSRIs such as citalopram, paroxetine, SNRIs such as duloxetine, venlafaxine, and tricyclics such as amitriptyline, doxepin), among others. The risk of serotonin syndrome may be more likely when you start or increase the dose of these medications.Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Avoid these products while using this medication. Ask your pharmacist for additional information.Limit your tyramine intake while using this medication and for 2 days after stopping treatment. Also avoid foods or drinks with high tyramine content during use because the combination may cause a serious rise in your blood pressure.Foods high in tyramine include those that may change as a result of aging, fermentation, pickling, or smoking. The tyramine content of any protein-rich food (meats, fish and dairy products) may increase if stored for long periods or improperly refrigerated. Some foods high in tyramine include aged cheeses (0 to 15 milligrams per ounce); fermented or air-dried meats (0.1 to 8 milligrams per ounce); sauerkraut (8 milligrams per 8 ounces); soy sauce (5 milligrams per 1 teaspoon); tap beers (4 milligrams per 12 ounces); red wines (0 to 6 milligrams per 8 ounces). Total intake of tyramine should be less than 100 milligrams per meal.Tell your doctor or pharmacist immediately if you notice symptoms of high blood pressure such as fast or pounding heartbeat, vomiting, sweating or headache, chest pain, sudden vision changes, weakness on one side of the body or slurred speech.Contact your healthcare professional (e.g., doctor, pharmacist or dietician) for more information, including recommendations for your diet.Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin. Be sure to ask your doctor or pharmacist if you should use additional reliable birth control methods while using this antibiotic.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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