(Lincocin) lincomycin hydrochloride

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is lincomycin (Lincocin), and how does it work (mechanism of action)?

Lincomycin (Lincocin) is an injectable man-made antibiotic. Lincomycin kills bacteria by interfering with the ability of bacteria to produce important proteins necessary for them to survive. Lincomycin is effective against many types of bacteria including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Propionibacterium acnes, and others. The FDA approved lincomycin in December 1964.

Lincocin warnings and side effects

WARNING (Black Box): Rare but sometimes fatal intestinal problems have occurred (pseudomembranous colitis) with use of lincomycin. Therefore, it should only be used to treat serious infections where less toxic antibiotics are not appropriate. It should not be used to treat nonbacterial infections such as upper respiratory infections.

Side effects of lincomycin are:

Like other antibiotics lincomycin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis).

Patients who develop signs of pseudomembranous colitis after treatment with lincomycin should contact their doctor or other health care professional immediately. Symptoms may include:

What is the dosage for lincomycin, and how is it administered?

Intramuscular

  • Adults: Inject 600 mg every 24 hours. May use 600 mg every 12 hours or more often for severe infections, if needed.
  • Pediatric patients of 1 month of age and older: Inject 10 mg/kg every 24 hours. May use 10 mg/kg every 12 hours or more often for severe infections, if needed.

IV

  • Adults: Administer 600 mg to 1000 mg every 8 to 12 hours. May increase doses for more severe infections, but the maximum daily dose of 8000 mg of lincomycin is recommended; higher rates and doses have been associated with severe cardiopulmonary reactions.
  • Pediatric patients of 1 month of age and older: Administer 10 to 20 mg/kg/day in divided doses over 8 to 12 hours.

Safe and effective use of lincomycin is not established for infants of age less than 1 month old.

Which drugs or supplements interact with this drug?

Lincomycin should be used with caution with neuromuscular blocking medications such as atracurium (Tracrium), pancuronium (Pavulon), rocuronium (Zemuron), succinylcholine (Anectine), and vecuronium. Lincomycin may increase the effects of neuromuscular blockage and lead to respiratory depression.

Medically Reviewed by a Doctor on 5/26/2017

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