linagliptin, Tradjenta (cont.)

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PREPARATIONS: Tablets: 5 mg

STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F)

PRESCRIBED FOR: Linagliptin is combined with diet and exercise to improve blood glucose levels in patients with type 2 diabetes.

DOSING: Linagliptin may be taken with or without food. The recommended dose is 5 mg once daily.

DRUG INTERACTIONS: Rifampin decreases the blood concentration of linagliptin by stimulating break down of linagliptin by CYP3A4 liver enzymes. Other drugs that increase activity CYP3A4 may also reduce the blood concentration of linagliptin.

PREGNANCY: There are no adequate studies of linagliptin in pregnant women.

NURSING MOTHERS: It is unknown whether linagliptin is secreted in human breast milk.

SIDE EFFECTS AND PRECAUTIONS: The most common side effects of linagliptin are stuffy or runny nose and sore throat. Hypoglycemia may occur when linagliptin is combined with insulin or a sulfonylurea-type drug. Allergic reactions and muscle pain also may occur. Pancreatitis also has been reported.

REFERENCE: FDA prescribing information.

Last Editorial Review: 5/19/2011

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