Lidocaine and prilocaine cream is not recommended in neonates with a gestational less than 37 weeks or infants younger than 12 months who are receiving treatment with methemoglobin-inducing agents.
DRUG INTERACTIONS: Lidocaine and prilocaine should not be used together with anti-arrhythmic drugs such as tocainide (Tonocard) and mexiletine (Mexitil), due to additive effects on heart rate and rhythm.
Prilocaine may contribute to formation of methemoglobin in patients treated with other drugs known to cause methemoglobinemia.
Lidocaine and prilocaine should be used with caution with anti-arrhythmic drugs like amiodarone (Cordarone), sotalol (Betapace), bretylium, and dofetilide (Tikosyn) because of increased risk developing abnormal heart rate and rhythm.
PREGNANCY: There are no adequate studies of lidocaine and prilocaine to determine safe and effective use in pregnant women.
NURSING MOTHERS: Lidocaine and prilocaine may be excreted in breast milk; therefore, caution should be exercised before using them in nursing mothers.
Medically reviewed by Eni Williams, PharmD
REFERENCE: FDA Prescribing Information.
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