lidocaine and prilocaine (DermacinRx, Prizopak, EMLA, Leva Set, Lidopril, Livixil Pak, LP Lite Pak)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: lidocaine and prilocaine

BRAND NAME: DermacinRx, Prizopak, EMLA, Leva Set, Lidopril, Livixil Pak, LP Lite Pak, Oraqix, Relador Pak, Venipuncture CPI



USES: Lidocaine and prilocaine cream is commonly used as a local anesthetic on normal intact skin and genital mucous areas, before minor procedures.

SIDE EFFECTS: Common side effects of lidocaine and prilocaine are:

  • application site redness,
  • pain,
  • burning,
  • paleness,
  • edema, and
  • altered temperature sensation.

Other rare side effects include:

  • shock,
  • central nervous system depression,
  • hypersensitivity reactions, and
  • hypotension (low blood pressure).

PREPARATIONS: Lidocaine and prilocaine is a combination cream, containing 2.5% of each component. Lidocaine and prilocaine is available in 5 gram and 30 gram tubes.

DRUG INTERACTIONS: Lidocaine and prilocaine should not be used together with anti-arrhythmic drugs such as tocainide (Tonocard) and mexiletine (Mexitil), due to additive effects on heart rate and rhythm.

Prilocaine may contribute to formation of methemoglobin in patients treated with other drugs known to cause methemoglobinemia.

Lidocaine and prilocaine should be used with caution with anti-arrhythmic drugs like amiodarone (Cordarone), sotalol (Betapace), bretylium, and dofetilide (Tikosyn) because of increased risk developing abnormal heart rate and rhythm.

Medically Reviewed by a Doctor on 8/1/2016

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