lidocaine viscous (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Toxicity may result when lidocaine is used with other local anesthetics or drugs which are structurally related to amide-type local anesthetics. Antiarrhythmic drugs such as mexiletine and amiodarone may increase blood concentrations of lidocaine.

Lidocaine is mainly metabolized or broken down by liver enzymes. Strong inhibitors of these liver enzymes such as fluvoxamine, erythromycin, and itraconazole may decrease the breakdown of lidocaine and cause an increase in its blood concentrations.

Cimetadine and beta blockers such as propranolol may decrease blood levels of lidocaine by decreasing blood flow to the liver or by inhibiting liver enzymes that break down lidocaine.

PREGNANCY: Lidocaine has not been adequately evaluated in pregnant women.

NURSING MOTHERS: Lidocaine and its metabolites are secreted into breast milk. At therapeutic doses the secretions in the breast milk are small and generally do not harm the infant; patients should consult their doctors before taking this drug.

Medically reviewed by Omudhome Ogbru, PharmD

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 9/18/2015

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