lidocaine viscous (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Children 2-12 years: Dosing is based on weight. Do not exceed 1 ml per 5 kg of child's weight per dose. Do not exceed 4 mg/kg or 4 doses in 24 hours.

DRUG INTERACTIONS: Lidocaine topical administration results in low systematic or blood levels are therefore does not have any known clinically significant drug-drug interactions. The following drug interactions have been observed with intravenous lidocaine use.

Toxicity may result when lidocaine is used with other local anesthetics or drugs which are structurally related to amide-type local anesthetics. Antiarrhythmic drugs such as mexiletine and amiodarone may increase blood concentrations of lidocaine.

Lidocaine is mainly metabolized or broken down by liver enzymes. Strong inhibitors of these liver enzymes such as fluvoxamine, erythromycin, and itraconazole may decrease the breakdown of lidocaine and cause an increase in its blood concentrations.

Cimetadine and beta blockers such as propranolol may decrease blood levels of lidocaine by decreasing blood flow to the liver or by inhibiting liver enzymes that break down lidocaine.

PREGNANCY: Lidocaine has not been adequately evaluated in pregnant women.

NURSING MOTHERS: Lidocaine and its metabolites are secreted into breast milk. At therapeutic doses the secretions in the breast milk are small and generally do not harm the infant; patients should consult their doctors before taking this drug.

SIDE EFFECTS: Common side effects are associated with the local application of lidocaine and may include stinging, burning, and mild nausea.

Serious adverse effects including allergic or anaphylactic reactions, drowsiness, dizziness, confusion, low blood pressure, irregular heart beats, cardiac arrest, blurry vision, seizures, and breathing problems have been reported with lidocaine use.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 10/13/2014

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