levothyroxine sodium, Synthroid, Levoxyl, Levothroid, Unithroid, Tirosint, Levo-T (cont.)

Pharmacy Author:

Omudhome Ogbru, PharmD

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

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Medical and Pharmacy Editor:

Jay W. Marks, MD

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Converting hypothyroidism to the euthyroid state with levothyroxine may increase the blood level of theophylline (Slo-Bid), and it may be necessary to change the dose of theophylline.

Taking levothyroxine at the same time as calcium carbonate, ferrous sulphate, cholestyramine (Questran) or colestipol (Colestid) may decrease the effect of levothyroxine and lead to hypothyroidism. This occurs because the levothyroxine binds to these drugs and is not absorbed. Taking the levothyroxine one hour before or four hours after these drugs is necessary to prevent binding.

PREGNANCY: Thyroid hormone therapy during pregnancy is usually safe but should be supervised by a physician.

NURSING MOTHERS: Thyroid hormone therapy in nursing mothers is usually safe but should be supervised by a physician.

SIDE EFFECTS: Levothyroxine therapy usually is well-tolerated. If symptoms occur, they often are due to toxic levels of thyroid hormone, and the symptoms are those of hyperthyroidism. Symptoms may include all or some of the following: chest pain, increased heart rate or pulse rate, excessive sweating, heat intolerance, nervousness, headache, insomnia, diarrhea, vomiting, weight loss, or fever. Women may experience irregular menstrual cycles.

Reference: FDA Prescribing Information

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