levofloxacin, Levaquin (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 250, 500 and 750 mg; Oral solution: 25 mg/mL; Injection: 500 mg/20 ml and 750 mg/30 ml; Premix ready to use injection: 250 mg/50 ml, 500 mg/100 ml, and 750 mg/150 ml.
STORAGE: Levofloxacin should be stored at 15 C to 30 C (59 F to 86 F)
DOSING: The usual dose is 250-750 mg given once daily for 3-14 days depending on the type of infection. Anthrax is treated with 500 mg daily for 60 days. It is important to take oral formulations at least 2 hours before or 2 hours after any antacid or mineral supplement containing iron, calcium, zinc, or magnesium since these bind levofloxacin and prevent its absorption into the body.
DRUG INTERACTIONS: Iron, calcium, zinc, or magnesium can attach to levofloxacin and other fluoroquinolones and prevent their absorption from the intestine into the blood. Therefore, products (for example, antacids) that contain iron, calcium, zinc or magnesium should be taken at least 2 hours before or 2 hours after levofloxacin. Other drugs that contain these minerals and can similarly interact with levofloxacin include sucralfate (Carafate) and didanosine (Videx, Videx EC).
Taking nonsteroidal anti-inflammatory drugs (NSAIDs) with levofloxacin may increase the risk of CNS stimulation, resulting in over-excitation. There have been reports of changes in blood sugar (increases and decreases) in patients treated with fluoroquinolones and antidiabetic agents. Fluoroquinolones may increase the effect of warfarin (Coumadin).
PREGNANCY: Levofloxacin is not recommended for use in pregnant women since levofloxacin causes joint and bone deformities in juvenile animals of several species.
NURSING MOTHERS: Levofloxacin is excreted in breas -milk. Mothers should decide whether to stop breastfeeding or discontinue levofloxacin.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 12/9/2014
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