levodopa-carbidopa, Sinemet, Sinemet CR, Parcopa (cont.)

Muscle twitching, dizziness, muscle jerks during sleep, and hand tremor also may occur.

Gastrointestinal side effects are also common in patients receiving carbidopa-levodopa and these include:

Patients may experience dizziness upon standing up, associated with a drop in blood pressure. Fortunately, the body develops tolerance to this side effect within a few months.

Infrequently, patients may develop a drop in white blood cell count during carbidopa-levodopa therapy. This is a reason to temporarily, if not permanently, stop treatment.

Other important side effects of carbidopa-levodopa therapy include psychiatric disturbances such as:

Gastrointestinal side effects are common in patients receiving carbidopa-levodopa. Nausea, vomiting, loss of appetite, and weight loss may occur. Patients may experience dizziness upon standing up, associated with a drop in blood pressure. Fortunately, the body develops tolerance to this side effect within a few months. Infrequently, patients may develop a drop in white blood cell count during carbidopa-levodopa therapy. This is a reason to temporarily, if not permanently, stop treatment.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets (carbidopa/levodopa): 10/100, 25/100 mg. Tablets (Controlled Release): 25/100 and 50/200 mg.

STORAGE: Tablets should be kept at room temperature, 15-30 C (59-86 F).

DOSING: Carbidopa-levodopa is taken several times per day. It may be administered with food to reduce the likelihood of nausea; however, a high-protein diet may reduce its absorption. The initial dose using regular tablets is 25/100 mg three times daily. The dose may be increased by one tablet every day or every other day until 8 tablets of 25/100 mg daily is reached. Alternatively 10/100 mg three or four times daily may be used initially and increased by one tablet daily or every other day until a total of eight tablets daily is reached. The dose of controlled release tablets is 50/200 mg twice daily and may increase up to 1.6 grams levodopa daily. Controlled release tablet should be given at least 6 hours apart.

Medically Reviewed by a Doctor on 12/30/2014


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