levetiracetam, Keppra, Keppra XR

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GENERIC NAME: levetiracetam

BRAND NAME: Keppra, Keppra XR

DRUG CLASS AND MECHANISM: Levetiracetam is an antiseizure (antiepileptic) drug. Its mechanism of action is unknown, but it inhibits the spread of seizure activity in the brain. In studies, addition of levetiracetam to other antiseizure drugs reduced the frequency of seizures more than placebo. The FDA approved levetiracetam in November 1999.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets (immediate release): 250, 500, 750 and 1000 mg. Tablets (extended release): 500 and 750 mg. Oral solution: 100 mg/ml. Injection solution: 5, 10, 15, and 100 mg/ml.

STORAGE: Levetiracetam should be stored at 25 C (77 F). Brief storage at 15 C to 30 C (59 F to 86 F) is acceptable.

PRESCRIBED FOR: Levetiracetam is used in combination with other anti-seizure medications to treat myoclonic, partial onset, or tonic clonic seizures in children and adults.

DOSING: The recommended daily dose of levetiracetam in adults is 3000 mg. Therapy is initiated with 1000 mg daily (500 mg twice daily) and increased by 1000 mg/day every two weeks up to the maximum recommended dose of 3000 mg/day.

Immediate release tablets, oral solution, and intravenous solutions are administered twice daily, and extended release tablets are administered once daily.

The recommended daily dose for children is 60 mg/kg (30 mg/kg twice daily). Therapy is initiated with 20 mg/kg (10 mg/kg twice daily) and increased by 20 mg/kg every two weeks until the recommended daily dose of 60 mg/kg is reached.

Medically Reviewed by a Doctor on 7/10/2014



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