leuprolide, (Lupron, Lupron Depot, Lupron Depot-Ped, Eligard)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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For endometriosis, the recommended dose of Lupron Depot is 3.75 mg monthly or 11.5 mg every 3 months. The recommended duration of treatment is 6 months.

Fibroids are treated with either a single 11.5 mg dose of Lupron Depot or 3.75 mg doses given monthly for up to 3 months.

The recommended starting dose of leuprolide for treating central precocious puberty is 50 mcg/kg/day. This dose can be increased by 10 mcg/kg/day depending on the response of the patient. Alternatively, Lupron Depot-Ped can be given at 7.5 mg (25 kg), 11.25 mg (25 to 37.5 kg), or 15 mg (>37.5 kg) intramuscular injection once a month. Alternatively 11.25 mg or 30 mg single dose can be administered every 3 months.

DRUG INTERACTIONS: No drug interaction studies have been done for leuprolide.

PREGNANCY: Leuprolide should not be administered to pregnant women because there is a high chance of harm to the fetus.

NURSING MOTHERS: The effects of leuprolide on the infant have not been studied in women who are breastfeeding.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 4/3/2015

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