For endometriosis, the recommended dose of Lupron Depot is 3.75 mg monthly or 11.5 mg every 3 months. The recommended duration of treatment is 6 months.
Fibroids are treated with either a single 11.5 mg dose of Lupron Depot or 3.75 mg doses given monthly for up to 3 months.
The recommended starting dose of leuprolide for treating central precocious puberty is 50 mcg/kg/day. This dose can be increased by 10 mcg/kg/day depending on the response of the patient. Alternatively, Lupron Depot-Ped can be given at 7.5 mg (¡Ü25 kg), 11.25 mg (25 to 37.5 kg), or 15 mg (>37.5 kg) intramuscular injection once a month. Alternatively 11.25 mg or 30 mg single dose can be administered every 3 months.
DRUG INTERACTIONS: No drug interaction studies have been done for leuprolide.
PREGNANCY: Leuprolide should not be administered to pregnant women because there is a high chance of harm to the fetus.
NURSING MOTHERS: The effects of leuprolide on the infant have not been studied in women who are breastfeeding.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
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