leuprolide, (Lupron, Lupron Depot, Lupron Depot-Ped, Eligard) (cont.)

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Depression, rare cases of suicidal behavior, low blood pressure, convulsions, joint pain and muscle aches have been reported in post-marketing surveillance.



PREPARATIONS: Leuprolide injection: 5 mg/ml and 3.75 mg . Lupron Depot microspheres for injection: 3.75, 7.5, 15, 11.25, 22.5, 30, and 45 mg/vial.

STORAGE: Leuprolide should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

DOSING: Leuprolide is injected under the skin (subcutaneously). Lupron Depot is injected into muscle (intramuscularly).

For prostate cancer, leuprolide can be given daily or Lupron Depot can be given monthly or at 3 to 4 month intervals. The daily dose of leuprolide is 1 mg. The 3.5 and 7.5 mg doses of Lupron Depot are injected monthly, the 11.25 and 22.5 mg doses every three months, the 30 mg dose every four months, and the 45 mg dose every 6 months.

For endometriosis, the recommended dose of Lupron Depot is 3.75 mg monthly or 11.5 mg every 3 months. The recommended duration of treatment is 6 months.

Fibroids are treated with either a single 11.5 mg dose of Lupron Depot or 3.75 mg doses given monthly for up to 3 months.

The recommended starting dose of leuprolide for treating central precocious puberty is 50 mcg/kg/day. This dose can be increased by 10 mcg/kg/day depending on the response of the patient. Alternatively, Lupron Depot-Ped can be given at 7.5 mg (25 kg), 11.25 mg (25 to 37.5 kg), or 15 mg (>37.5 kg) intramuscular injection once a month. Alternatively 11.25 mg or 30 mg single dose can be administered every 3 months.

DRUG INTERACTIONS: No drug interaction studies have been done for leuprolide.

PREGNANCY: Leuprolide should not be administered to pregnant women because there is a high chance of harm to the fetus.

NURSING MOTHERS: The effects of leuprolide on the infant have not been studied in women who are breastfeeding.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 4/3/2015

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