leuprolide, (Lupron, Lupron Depot, Lupron Depot-Ped, Eligard)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PRESCRIBED FOR: Leuprolide is used for the treatment of advanced prostatic cancer, endometriosis, fibroids, and central precocious puberty.

SIDE EFFECTS: The most common side effects of leuprolide are:

Other important side effects of leuprolide include:

Depression, rare cases of suicidal behavior, low blood pressure, convulsions, joint pain and muscle aches have been reported in post-marketing surveillance.

PRESCRIPTION: Yes.

GENERIC AVAILABLE: Yes.

PREPARATIONS: Leuprolide injection: 5 mg/ml and 3.75 mg . Lupron Depot microspheres for injection: 3.75, 7.5, 15, 11.25, 22.5, 30, and 45 mg/vial.

STORAGE: Leuprolide should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).

DOSING: Leuprolide is injected under the skin (subcutaneously). Lupron Depot is injected into muscle (intramuscularly).

For prostate cancer, leuprolide can be given daily or Lupron Depot can be given monthly or at 3 to 4 month intervals. The daily dose of leuprolide is 1 mg. The 3.5 and 7.5 mg doses of Lupron Depot are injected monthly, the 11.25 and 22.5 mg doses every three months, the 30 mg dose every four months, and the 45 mg dose every 6 months.

Medically Reviewed by a Doctor on 4/3/2015

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