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In this Article

• Introduction
• What causes Leukoplakia?
• What are the symptoms?
• How is Leukoplakia diagnosed?
• How is Leukoplakia treated?
• Find a local Doctor in your town
• Leukoplakia Index

• Irritation from rough teeth, fillings, or crowns, or ill-fitting dentures that rub against your cheek or gum
• Chronic smoking, pipe smoking, or other tobacco use
• Sun exposure to the lips
• Oral cancer, although rare
• HIV or AIDS

The presence of white or gray colored patches on your tongue, gums, roof of your mouth, or the inside of the cheeks of your mouth may be a sign of leukoplakia. The patch may have developed slowly over weeks to months and be thick, slightly raised, and may eventually take on a hardened and rough texture. It usually is painless, but may be sensitive to touch, heat, spicy foods, or other irritation.

Your dentist may suspect leukoplakia upon examination; however, a biopsy will likely be taken to rule out other causes, such as oral cancer. During the biopsy, a small piece of tissue from the lesion will be removed to be examined in a lab. A numbing agent will be used so that you will not feel any pain.

Treatment, if needed, involves removing the source of irritation. For example, if leukoplakia is caused by a rough tooth or an irregular surface on a denture or filling the tooth will be smoothed and dental appliances repaired. If leukoplakia is caused by smoking, you will be asked to minimize or stop smoking or using other tobacco products.

Leukoplakia is usually harmless, and lesions usually clear in a few weeks or months after the source of irritation is removed. If eliminating the source of irritation is ineffective in reducing leukoplakia, the lesion may need to be surgically removed. The lesion can be removed either by your general dentist or by an oral surgeon in their office under local anesthesia.

Hairy leukoplakia requires treatment with an antiviral medication.

Reviewed by the doctors at The Cleveland Clinic Department of Dentistry.
Edited by Charlotte E. Grayson, MD, May 2005, WebMD.

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