letrozole, Femara

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is letrozole, and how does it work (mechanism of action)?

Letrozole is an oral, anti-estrogen drug that is used for treating postmenopausal women with breast cancer. The growth of some breast cancers in postmenopausal women is promoted by estrogens that circulate in the blood, and the adrenal glands are the main source of these circulating estrogens. Letrozole inhibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Letrozole was approved by the FDA in 1997.

What brand names are available for letrozole?

Femara

Is letrozole available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for letrozole?

Yes

What are the side effects of letrozole?

The most common side effects with letrozole are:

Cholesterol levels may increase during letrozole therapy. Cholesterol levels should be monitored and some patients may require treatment for high cholesterol levels. Letrozole decreases bone mineral density, increasing the risk of osteoporosis and fractures.

Medically Reviewed by a Doctor on 9/14/2015

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