letrozole, Femara

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GENERIC NAME: letrozole


DRUG CLASS AND MECHANISM: Letrozole is an oral, anti-estrogen drug that is used for treating postmenopausal women with breast cancer. The growth of some breast cancers in postmenopausal women is promoted by estrogens that circulate in the blood, and the adrenal glands are the main source of these circulating estrogens. Letrozole inhibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Letrozole was approved by the FDA in 1997.

PRESCRIBED FOR: Letrozole is used to treat postmenopausal women with hormone receptor positive early breast cancer or who have been treated with tamoxifen (Nolvadex). It also is approved for initial or second-line treatment of postmenopausal women with hormone-sensitive or advanced breast cancer.

Medically Reviewed by a Doctor on 9/14/2015

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