Medications and Drugs
GENERIC NAME: letrozole
BRAND NAME: Femara
DRUG CLASS AND MECHANISM: Letrozole is an oral, anti-estrogen drug that is used for treating postmenopausal women with breast cancer. The growth of some breast cancers in postmenopausal women is promoted by estrogens that circulate in the blood, and the adrenal glands are the main source of these circulating estrogens. Letrozole inhibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Letrozole was approved by the FDA in 1997.
GENERIC AVAILABLE: no
PRESCRIPTION: yes
PREPARATIONS: Tablets: 2.5mg.
STORAGE: Tablets should be stored at room temperature, 15-30 °C (59-86 °F).
PRESCRIBED FOR: Letrozole is used to treat postmenopausal women
with breast cancer that is resistant to the more commonly-used anti-estrogen medications such
as tamoxifen (Nolvadex). It
also is approved for treating postmenopausal women after surgery who have
hormone-sensitive early breast cancer.
DOSING: Letrozole generally is taken once daily, with or without food.
DRUG INTERACTIONS: There are no known drug interactions with
letrozole.
PREGNANCY: Letrozole damages the fetus. It should not
be taken by pregnant women.
NURSING MOTHERS: It is not known if letrozole is secreted into
breast milk.
SIDE EFFECTS: The most common side effects with letrozole are
nausea, vomiting, fatigue, headache, muscle aches, diarrhea, constipation,
and chest pain. The likelihood of side effects is lower than with other
drugs used more commonly in patients with breast cancer that is resistant to treatment with anti-estrogens, for example, megestrol (Megace).
Reference: FDA Prescribing Information
Last Editorial Review: 2/7/2006
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