GENERIC NAME: LEPIRUDIN - INJECTABLE (leh-PEER-oo-din)
BRAND NAME(S): Refludan
Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert
USES: Lepirudin is a "blood thinner" (anticoagulant) used to treat patients who have developed a reaction to another type of anticoagulant (patients with heparin-induced thrombocytopenia). It is also used along with antiplatelet therapy (e.g., aspirin) to treat worsening angina/chest pain and certain types of heart attacks (Acute Coronary Syndrome-ACS).
HOW TO USE: Follow all instructions for proper mixing, dilution with the correct IV fluids, and monitoring of treatment (e.g., aPTT monitoring). If you have any questions regarding the use of this medication, consult your pharmacist Give the initial bolus dose of this medication by vein (IV) over 15 to 20 seconds followed by a continuous IV infusion mixed in a saline (NS) or dextrose-based (D5W) solution as directed by your doctor. The dosage and length of treatment is based on your weight, medical condition, and response to therapy. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.
SIDE EFFECTS: Injection site reactions (e.g., redness, discomfort) may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising or bleeding, pink or red-colored urine, black or bloody stool, coffee-ground vomit, one-sided weakness, vision problems, nausea/vomiting, confusion, slurred speech, weakness, dizziness. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fever, yellowing eyes or skin, dark urine. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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