Leigh's Syndrome (Leigh's Disease) (cont.)
In this Article
Is there any treatment for Leigh's disease?
The most common treatment for Leigh's disease is thiamine or Vitamin B1. Oral sodium bicarbonate or sodium citrate may also be prescribed to manage lactic acidosis. Researchers are currently testing dichloroacetate to establish its effectiveness in treating lactic acidosis. In individuals who have the X-linked form of Leigh's disease, a high-fat, low-carbohydrate diet may be recommended.
Are there other forms of Leigh's disease?
There is also a form of Leigh's disease (called X-linked Leigh's disease) which is the result of mutations in a gene that produces another group of substances that are important for cell metabolism. This gene is only found on the X chromosome.
What is the prognosis for Leigh's disease?
The prognosis for individuals with Leigh's disease is poor. Individuals who lack mitochondrial complex IV activity and those with pyruvate dehydrogenase deficiency tend to have the worst prognosis and die within a few years. Those with partial deficiencies have a better prognosis, and may live to be 6 or 7 years of age. Some have survived to their mid-teenage years.
What research is being done with Leigh's disease?
The NINDS supports and encourages a broad range of basic and clinical research on neurogenetic disorders such as Leigh's disease. The goal of this research is to understand what causes these disorders and then to apply these findings to new ways to diagnose, treat, and prevent them.
Clinical trials for Leigh's disease
NIH Patient Recruitment for Leigh's Disease Clinical Trials
Medically Reviewed by a Doctor on 4/2/2014
Viewers share their comments
Leigh's Disease - Symptoms Question: Please describe the symptoms of Leigh's disease in a friend or family member.
Leigh's Disease - Treatment Question: If someone you know had Leigh's disease, what was the treatment?
Leigh's Disease - Support Question: Did you or someone you know receive support for a child with Leigh's disease? Please share information.
- Allergic Skin Disorders
- Bacterial Skin Diseases
- Bites and Infestations
- Diseases of Pigment
- Fungal Skin Diseases
- Medical Anatomy and Illustrations
- Noncancerous, Precancerous & Cancerous Tumors
- Oral Health Conditions
- Papules, Scales, Plaques and Eruptions
- Scalp, Hair and Nails
- Sexually Transmitted Diseases (STDs)
- Vascular, Lymphatic and Systemic Conditions
- Viral Skin Diseases
- Additional Skin Conditions