latanoprost, Xalatan (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: The usual dose is one drop into the affected eye or eyes once daily in the evening. The hands should be washed before each use of latanoprost or any eye medication. Contact lenses should be removed. The head is tilted back and the lower eyelid is pulled down with the index finger to form a pouch. (It is important not to touch the tip of the dropper to the eye or the eyelid so that bacteria are not introduced into the bottle.) The bottle is squeezed slightly to allow the prescribed number of drops into the pouch. The eye is closed gently for 2 to 3 minutes without blinking.
DRUG INTERACTIONS: Mixing eye drops containing thimerosal with latanoprost may cause precipitation of the chemicals within the drops. Therefore, thimerosal eye drops and latanoprost should be administered at least 5 minutes apart. Combining latanoprost with other prostaglandin eye drops may reduce the effect of latanoprost and may even increase intraocular pressure.
PREGNANCY: There are no adequate studies in pregnant women. Physicians should use latanoprost during pregnancy only if its benefits are felt to outweigh the potential risks to the fetus.
NURSING MOTHERS: It is not known if latanoprost is secreted into breast milk.
SIDE EFFECTS: Between 5% and 15% (between 1 in 20 and 1 in 6) of persons receiving latanoprost for 6 months report at least one side effect localized to the eyes. These side effects included blurred vision, redness, a sensation of a foreign body, discoloration of the iris, itching, burning, and stinging. Discoloration of the iris begins slowly. It is caused by an increase in the amount of brown pigment in the iris and may be permanent. Other side effects which have been reported less frequently include dryness of the eyes, increased tearing, eye pain and other eye-related discomfort. Eyelash changes such as increased length, thickness, and number of lashes may occur. Conjunctivitis, double vision, and eye discharge are rare side effects of latanoprost.
Reference: FDA Prescribing Information
Last Editorial Review: 8/2/2012
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