Larynx Cancer (cont.)


Chemotherapy uses drugs to kill cancer cells. The drugs that treat laryngeal cancer are usually given through a vein (intravenous). The drugs enter the bloodstream and travel throughout your body.

Chemotherapy and radiation therapy are often given at the same time. You may receive chemotherapy in an outpatient part of the hospital, at the doctor's office, or at home. Some people need to stay in the hospital during treatment.

The side effects depend mainly on which drugs are given and how much. Chemotherapy kills fast-growing cancer cells, but the drugs can also harm normal cells that divide rapidly:

  • Blood cells: When drugs lower the levels of healthy blood cells, you're more likely to get infections, bruise or bleed easily, and feel weak and tired. Your health care team will check for low levels of blood cells. If your levels are low, your health care team may stop the chemotherapy for a while or reduce the dose of the drug.
  • Cells in hair roots: Chemotherapy may cause hair loss. If you lose your hair, it will grow back, but it may change in color and texture.
  • Cells that line the digestive tract: Chemotherapy can cause a poor appetite, nausea and vomiting, diarrhea, or mouth and lip sores. Your health care team can give you medicines and suggest other ways to help with these problems.

Also, chemotherapy can cause painful mouth and gums, dry mouth, infection, and changes in taste. Some drugs used for laryngeal cancer can cause tingling or numbness in the hands or feet. You may have these problems only during treatment or for a short time after treatment ends.

Targeted Therapy

Some people with laryngeal cancer receive a type of treatment known as targeted therapy. It may be given along with radiation therapy.

Cetuximab (Erbitux) was the first targeted therapy approved for laryngeal cancer. Cetuximab binds to cancer cells and interferes with cancer cell growth and the spread of cancer. You may receive cetuximab through a vein once a week for several weeks at the doctor's office, hospital, or clinic.

During treatment, your health care team will watch for signs of problems. Some people get medicine to prevent a possible allergic reaction. Side effects may include rash, fever, headache, vomiting, and diarrhea. These effects usually become milder after the first treatment.

You may want to ask your doctor these questions about chemotherapy or targeted therapy:

  • Why do I need this treatment?
  • Which drug or drugs will I have
  • How does the drug work?
  • When will treatment start? When will it end?
  • How will I feel during treatment? What are the side effects? Are there any lasting side effects? What can I do about them?

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