- What is lapatinib, and how does it work (mechanism of action)?
- What brand names are available for lapatinib?
- Is lapatinib available as a generic drug?
- Do I need a prescription for lapatinib?
- What are the side effects of lapatinib?
- What is the dosage for lapatinib?
- Which drugs or supplements interact with lapatinib?
- Is lapatinib safe to take if I'm pregnant or breastfeeding?
- What else should I know about lapatinib?
What is lapatinib, and how does it work (mechanism of action)?
Lapatinib is an oral medication used for treating breast cancer. Lapatinib is classified as a kinase inhibitor. Kinase inhibitors include
- dasatinib (Sprycel),
- erlotinib (Tarceva),
- gefitinib (Iressa),
- imatinib (Gleevec),
- pazopanib (Votrient),
- sunitinib (Sutent), and
- vandetanib (Caprelsa).
Kinase inhibitors prevent the growth of tumors by reducing the action of proteins that control cell division, growth and survival. These proteins usually are present in larger quantities or are more active in cancer cells. By reducing the activity of these proteins, growth and survival of cancer cells are reduced. The FDA approved lapatinib in March, 2007.
What brand names are available for lapatinib?
Is lapatinib available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for lapatinib?
What are the side effects of lapatinib?
Common side effects include:
- Reduced number of blood cells
- Shortness of breath
- Back pain
- Pain in extremities
- Sun sensitivity
- Hair loss
- Dry skin
- Weight loss
- Abnormal liver test results
Other side effects and adverse reactions include
- Lapatinib may cause a type of abnormal heart rhythm called prolongation of the QT interval. Prolongation of the QT interval may lead to sudden death. ECGs should be obtained prior to starting lapatinib. Low potassium or low magnesium may increase the risk of QT prolongation. Therefore, low potassium and low magnesium should be corrected prior to starting treatment. Food and/or drugs that reduce the breakdown of lapatinib in the liver and/or medicinal products that prolong the QT interval may increase the risk of QT prolongation and should not be combined with lapatinib.
Quick GuideBreast Cancer Diagnosis and Treatment
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