lansoprazole, Prevacid, Prevacid SoluTab (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
STORAGE: Store at room temperature, 15-30 C (59-86 F). Keep away from moisture.
PRESCRIBED FOR: Lansoprazole is used for treating ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome.
DOSING: For initial treatment of duodenal ulcers the recommended dose for adults is 15 mg daily for 4 weeks.
For the treatment of GERD, the recommended initial treatment is 15 mg for up to 8 weeks.
For maintaining healing (long-term) in duodenal ulcer and GERD the recommended treatment is 15 mg daily.
For initial treatment of severe (erosive) esophagitis and gastric ulcer, the recommended dose for adults is 30 mg daily for 4-8 weeks.
For the management of Zollinger-Ellison Syndrome, the starting dose for adults is 60 mg daily, and the dose is adjusted based on response. Doses up to 180 mg have been used in some patients with Zollinger-Ellison syndrome.
Intravenous lansoprazole is approved for patients who are unable to take oral lansoprazole. The approved intravenous dose is 30 mg daily for up to 7 days.
It is recommended that capsules be taken before meals for maximum effect. Capsules should be swallowed whole and should not be crushed, split or chewed.
For those with difficulty swallowing, the capsule should be opened and the granular contents sprinkled on a tablespoon of apple sauce, ENSURE pudding, cottage cheese, yogurt or strained pears and swallowed immediately. Granules also may be mixed in two ounces (60 ml) of apple, orange or tomato juice and swallowed immediately. For patients with a nasogastic tube, mix the granules can be mixed in two ounces of apple juice and injected through the nasogastric tube.
The absorption of certain drugs may be affected by stomach acidity, and, as a result, lansoprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively.
PREGNANCY: Use of lansoprazole in pregnant women has not been adequately evaluated.
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